“Greener” synthesis of bisphosphonic/dronic acid derivatives
Abstract: According to literature, the synthesis of dronic acid derivatives from the corresponding carboxylic acids using phosphorus trichloride and phosphorous acid as the P-reactants is controversial, due to the wide range of molar ratios and diverse conditions. In this minireview, we summarize our results on the clarification of these problems. For example, with zoledronic acid and risedronic acid, we found that, using methanesulfonic acid (MSA) as the solvent, 3.2 equivalents of phosphorus trichloride was enough. Generalizing this optimized method, etidronate, fenidronate, ibandronate and alendronate were obtained in yields of 38%–57%, which is reasonable for valuable dronates, and in most cases, with high purities. Mechanistic aspects are also discussed.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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“Greener” synthesis of bisphosphonic/dronic acid derivatives ; volume:3 ; number:2 ; year:2014 ; pages:111-116 ; extent:6
Green processing & synthesis ; 3, Heft 2 (2014), 111-116 (gesamt 6)
- Creator
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Kovács, Rita
Grün, Alajos
Garadnay, Sándor
Greiner, István
Keglevich, György
- DOI
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10.1515/gps-2013-0107
- URN
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urn:nbn:de:101:1-2501120303434.388473848885
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:27 AM CEST
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Associated
- Kovács, Rita
- Grün, Alajos
- Garadnay, Sándor
- Greiner, István
- Keglevich, György
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