Lipid homeostasis in mitochondria

Abstract: Mitochondria are surrounded by the two membranes, the outer and inner membranes, whose lipid compositions are optimized for proper functions and structural organizations of mitochondria. Although a part of mitochondrial lipids including their characteristic lipids, phosphatidylethanolamine and cardiolipin, are synthesized within mitochondria, their precursor lipids and other lipids are transported from other organelles, mainly the ER. Mitochondrially synthesized lipids are re-distributed within mitochondria and to other organelles, as well. Recent studies pointed to the important roles of inter-organelle contact sites in lipid trafficking between different organelle membranes. Identification of Ups/PRELI proteins as lipid transfer proteins shuttling between the mitochondrial outer and inner membranes established a part of the molecular and structural basis of the still elusive intra-mitochondrial lipid trafficking.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Lipid homeostasis in mitochondria ; volume:401 ; number:6-7 ; year:2020 ; pages:821-833 ; extent:13 ; Biological chemistry ; 401, Heft 6-7 (2020), 821-833 (gesamt 13)

Beteiligte, Orts- und Zeitangaben

• Urheber: Tamura, Yasushi ; Kawano, Shin ; Endo, Toshiya

Weitere Informationen

• DOI: 10.1515/hsz-2020-0121
• URN: urn:nbn:de:101:1-2408061711525.664786555834
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 14.08.2025, 10:56 MESZ