Hepatocyte nuclear factor 4α multiple isoforms, their functions, and their interactomes
Abstract: Hepatocyte nuclear factor 4‐alpha (HNF4α) is a master regulator gene belonging to the nuclear receptor superfamily and is involved in regulating a wide range of critical biological processes in different organs. Structurally, the HNF4A locus is organized into two independent promoters and is subjected to alternative splicing to produce twelve distinct isoforms. However, little is known about the biological impact of each isoform and the mechanisms by which they regulate transcription. Proteomic analyses have led to the identification of proteins that interact with specific HNF4α isoforms. The identification and validation of these interactions and their roles in the co‐regulation of targeted gene expression are essential to better understand the role of this transcription factor in different biological processes and pathologies. This review addresses the discoveries of different HNF4α isoforms and the main functions of the P1 and P2 isoform subgroups. It also provides information on the most recent focus areas in research on the nature and function of proteins associated with each of the isoforms in some biological contexts.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Hepatocyte nuclear factor 4α multiple isoforms, their functions, and their interactomes ; volume:23 ; number:13-14 ; year:2023 ; extent:15
Proteomics ; 23, Heft 13-14 (2023) (gesamt 15)
- Creator
-
Herrera‐Pulido, Jehison Alirio
Boisvert, Francois‐Michel
Boudreau, Francois
- DOI
-
10.1002/pmic.202200372
- URN
-
urn:nbn:de:101:1-2023072115320280928631
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
14.08.2025, 10:59 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Herrera‐Pulido, Jehison Alirio
- Boisvert, Francois‐Michel
- Boudreau, Francois
Other Objects (12)
Expression profile analysis of the inflammatory response regulated by hepatocyte nuclear factor 4α
Die Bedeutung des Transkriptions-hepatocyte-nuclear-factor-4α [Transkriptions-hepatocyte-nuclear-factor-4-alpha] für die Repression des Erythropoietin-Gens durch Interleukin-1β [Interleukin-1-beta]
Nuclear weapons and their effects
Identification of erythropoietin isoforms and evaluation of their biological importance
A Review of Metallothionein Isoforms and their Role in Pathophysiology
Conversion of hepatoma cells to hepatocyte-like cells by defined hepatocyte nuclear factors
Hepatocyte and keratinocyte growth factors and their receptors in human lung emphysema
Distinguishing Specific CXCL12 Isoforms on Their Angiogenesis and Vascular Permeability Promoting Properties
Multi-faceted quantitative proteomics analysis of histone H2B isoforms and their modifications
The Akt isoforms, their unique functions and potential as anticancer therapeutic targets
Nuclear morphologies: their diversity and functional relevance
Efficient hepatocyte differentiation of primary human hepatocyte-derived organoids using three dimensional nanofibers (HYDROX) and their possible application in hepatotoxicity research
Expression profile analysis of the inflammatory response regulated by hepatocyte nuclear factor 4α
Die Bedeutung des Transkriptions-hepatocyte-nuclear-factor-4α [Transkriptions-hepatocyte-nuclear-factor-4-alpha] für die Repression des Erythropoietin-Gens durch Interleukin-1β [Interleukin-1-beta]
Nuclear weapons and their effects
Identification of erythropoietin isoforms and evaluation of their biological importance
A Review of Metallothionein Isoforms and their Role in Pathophysiology
Conversion of hepatoma cells to hepatocyte-like cells by defined hepatocyte nuclear factors
Hepatocyte and keratinocyte growth factors and their receptors in human lung emphysema
Distinguishing Specific CXCL12 Isoforms on Their Angiogenesis and Vascular Permeability Promoting Properties
Multi-faceted quantitative proteomics analysis of histone H2B isoforms and their modifications
The Akt isoforms, their unique functions and potential as anticancer therapeutic targets
Nuclear morphologies: their diversity and functional relevance
Efficient hepatocyte differentiation of primary human hepatocyte-derived organoids using three dimensional nanofibers (HYDROX) and their possible application in hepatotoxicity research
Expression profile analysis of the inflammatory response regulated by hepatocyte nuclear factor 4α
Die Bedeutung des Transkriptions-hepatocyte-nuclear-factor-4α [Transkriptions-hepatocyte-nuclear-factor-4-alpha] für die Repression des Erythropoietin-Gens durch Interleukin-1β [Interleukin-1-beta]
Nuclear weapons and their effects
Identification of erythropoietin isoforms and evaluation of their biological importance
A Review of Metallothionein Isoforms and their Role in Pathophysiology
Conversion of hepatoma cells to hepatocyte-like cells by defined hepatocyte nuclear factors
Hepatocyte and keratinocyte growth factors and their receptors in human lung emphysema
Distinguishing Specific CXCL12 Isoforms on Their Angiogenesis and Vascular Permeability Promoting Properties
Multi-faceted quantitative proteomics analysis of histone H2B isoforms and their modifications
The Akt isoforms, their unique functions and potential as anticancer therapeutic targets
Nuclear morphologies: their diversity and functional relevance