Metabolomics paves the way for improved drug target identification
Correctly identifying candidate drugs for protein targets is crucial for drug discovery. Despite the importance of this problem for the pharmaceutical industry, chemical screening remains a challenging task, and drug–target misidentification may contribute to failures in drug development. In their recent study, Sauer and colleagues (Holbrook‐Smith et al, 2022) demonstrate proof‐of‐concept for a new way to identify drug–target interactions using high‐throughput metabolomics, potentially paving the way towards a universal method for predicting drug–target relationships.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Metabolomics paves the way for improved drug target identification ; volume:18 ; number:2 ; year:2022 ; extent:2
Molecular systems biology ; 18, Heft 2 (2022) (gesamt 2)
- Creator
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Garana, Belinda B.
Graham, Nicholas A.
- DOI
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10.15252/msb.202210914
- URN
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urn:nbn:de:101:1-2022022314122903581768
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:27 AM CEST
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Associated
- Garana, Belinda B.
- Graham, Nicholas A.
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Integrating metabolomics and proteomics to identify novel drug targets for heart failure and atrial fibrillation
Improved batch correction in untargeted MS-based metabolomics
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Evaluating the “wrong-way-round” electrospray ionization of antiretroviral drugs for improved detection sensitivity
Improved drug target deconvolution with PISA‐DIA using an extended, overlapping temperature gradient
Phosphodiesterases as drug targets
Transporters as drug targets
GWAS and drug targets
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