The feat of packaging eight unique genome segments
Abstract: Influenza A viruses (IAVs) harbor a segmented RNA genome that is organized into eight distinct viral ribonucleoprotein (vRNP) complexes. Although a segmented genome may be a major advantage to adapt to new host environments, it comes at the cost of a highly sophisticated genome packaging mechanism. Newly synthesized vRNPs conquer the cellular endosomal recycling machinery to access the viral budding site at the plasma membrane. Genome packaging sequences unique to each RNA genome segment are thought to be key determinants ensuring the assembly and incorporation of eight distinct vRNPs into progeny viral particles. Recent studies using advanced fluorescence microscopy techniques suggest the formation of vRNP sub-bundles (comprising less than eight vRNPs) during their transport on recycling endosomes. The formation of such sub-bundles might be required for efficient packaging of a bundle of eight different genomes segments at the budding site, further highlighting the complexity of IAV genome packaging
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Anmerkungen
-
Viruses. 8, 6 (2016), 165, DOI 10.3390/v8060165, issn: 1999-4915
IN COPYRIGHT http://rightsstatements.org/page/InC/1.0 rs
- Schlagwort
-
Influenzaviren
Influenza-A-Virus
Atemwegskrankheit
Atemnot
- Ereignis
-
Veröffentlichung
- (wo)
-
Freiburg
- (wer)
-
Universität
- (wann)
-
2016
- DOI
-
10.3390/v8060165
- URN
-
urn:nbn:de:bsz:25-freidok-132194
- Rechteinformation
-
Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:32 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Giese, Sebastian
- Bolte, Hardin
- Schwemmle, Martin
- Universitätsklinikum Freiburg. Institut für Virologie
- Universitätsklinikum Freiburg. Department für Medizinische Mikrobiologie und Hygiene
- Universitätsklinikum Freiburg
- Spemann Graduate School of Biology and Medicine
- Albert-Ludwigs-Universität Freiburg
- Universität
Entstanden
- 2016