The feat of packaging eight unique genome segments

Abstract: Influenza A viruses (IAVs) harbor a segmented RNA genome that is organized into eight distinct viral ribonucleoprotein (vRNP) complexes. Although a segmented genome may be a major advantage to adapt to new host environments, it comes at the cost of a highly sophisticated genome packaging mechanism. Newly synthesized vRNPs conquer the cellular endosomal recycling machinery to access the viral budding site at the plasma membrane. Genome packaging sequences unique to each RNA genome segment are thought to be key determinants ensuring the assembly and incorporation of eight distinct vRNPs into progeny viral particles. Recent studies using advanced fluorescence microscopy techniques suggest the formation of vRNP sub-bundles (comprising less than eight vRNPs) during their transport on recycling endosomes. The formation of such sub-bundles might be required for efficient packaging of a bundle of eight different genomes segments at the budding site, further highlighting the complexity of IAV genome packaging

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch
Anmerkungen
Viruses. 8, 6 (2016), 165, DOI 10.3390/v8060165, issn: 1999-4915
IN COPYRIGHT http://rightsstatements.org/page/InC/1.0 rs

Schlagwort
Influenzaviren
Influenza-A-Virus
Atemwegskrankheit
Atemnot

Ereignis
Veröffentlichung
(wo)
Freiburg
(wer)
Universität
(wann)
2016
Urheber

DOI
10.3390/v8060165
URN
urn:nbn:de:bsz:25-freidok-132194
Rechteinformation
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Letzte Aktualisierung
15.08.2025, 07:32 MESZ

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