Exploring the Intracellular Distribution of Se Compounds Delivered by Biodegradable Polyelectrolyte Capsules Using X‐Ray Fluorescence Imaging
Abstract: Selenium (Se) compounds hold promise as potential therapeutics for cancer due to their diverse biological functions and redox‐regulating properties. In this study, the encapsulation of a hydrophobic selenium compound inside 5 µm sized biodegradable polyelectrolyte capsules consisting of poly‐L‐arginine and dextran is investigated. While the encapsulated form of the compound showed comparable cellular uptake and cytotoxicity as the free drug, e.g. no improved anti‐cancer efficacy is achieved, the investigation yielded crucial insights. Utilizing subcellular resolution synchrotron X‐ray fluorescence imaging (XFI), the intracellular location of the Se compound is successfully visualized by demonstrating the degradation of the capsules and the following redistribution of the compound, without exogenous labeling. By applying a quantitative fitting approach, the intracellular Se mass is determined to be 0.09 ± 0.01 pg after degradation of the carrier. This highlights the potential of XFI as a powerful tool for tracking intracellular dynamics of metal‐based drugs, which may facilitate drug development in the clinic.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Exploring the Intracellular Distribution of Se Compounds Delivered by Biodegradable Polyelectrolyte Capsules Using X‐Ray Fluorescence Imaging ; day:06 ; month:11 ; year:2024 ; extent:9
Advanced functional materials ; (06.11.2024) (gesamt 9)
- Creator
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Skiba, Marvin
Reszegi, Rebeka R.
Huang, Yalan
Roy, Sathi
Han, Jili
Brückner, Dennis
Sanchez‐Cano, Carlos
Zhao, Ying
Hassan, Moustapha
Feliu, Neus
Falkenberg, Gerald
Parak, Wolfgang J.
- DOI
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10.1002/adfm.202408539
- URN
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urn:nbn:de:101:1-2411061348519.211842991618
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:37 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Skiba, Marvin
- Reszegi, Rebeka R.
- Huang, Yalan
- Roy, Sathi
- Han, Jili
- Brückner, Dennis
- Sanchez‐Cano, Carlos
- Zhao, Ying
- Hassan, Moustapha
- Feliu, Neus
- Falkenberg, Gerald
- Parak, Wolfgang J.
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