Cerebrospinal fluid analysis in patients with COVID-19-associated central nervous system manifestations: a systematic review
Abstract: Background: Central nervous system (CNS) symptoms may occur in patients with acute COVID-19. The role of CSF examination in these patients remains to be established. Objective: A systematic review of CSF findings relating to COVID-19 was carried out. Methods: CSF parameters, including cytological and biochemical analyses, SARS-CoV-2 RT-PCR and other CSF markers, were recorded and analyzed among patients with acute COVID-19 and one of the following CNS syndromes: stroke, encephalopathy, encephalitis, inflammatory syndromes, seizure, headache and meningitis. Results: Increased white blood cells and/or increased protein concentration were found in 52.7% of the patients with encephalitis, 29.4% of the patients with encephalopathy and 46.7% of the patients with inflammatory syndromes (P < 0.05). CSF RT-PCR for SARS-CoV-2 was positive in 17.35% of the patients with encephalitis and less than 3.5% of the patients with encephalopathy or inflammatory syndromes (P < 0.05). Intrathecal production of immunoglobulins was found in only 8% of the cases. More than 85% of the patients had increased CSF cytokines and chemokines. Increased CSF neurofilament light chain (NfL) and CSF Tau were found in 71% and 36% of the cases, respectively. Conclusion: Non-specific inflammatory CSF abnormalities were frequently found in patients with COVID-19 CNS syndromes. The increase in neurodegeneration biomarkers suggests that neuronal damage occurs, with long-term consequences that are still unknown.
- Alternative title
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Análise do líquido cefalorraqueano em pacientes com manifestações neurológicas do sistema nervoso central associadas à COVID-19: revisão sistemática
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Cerebrospinal fluid analysis in patients with COVID-19-associated central nervous system manifestations: a systematic review ; volume:80 ; number:03 ; year:2022 ; pages:296-305
Arquivos de neuro-psiquiatria ; 80, Heft 03 (2022), 296-305
- Contributor
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Domingues, Renan Barros
Leite, Fernando Brunale Vilela de Moura
Senne, Carlos
- DOI
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10.1590/0004-282X-ANP-2021-0117
- URN
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urn:nbn:de:101:1-2023031611034745239685
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:47 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Domingues, Renan Barros
- Leite, Fernando Brunale Vilela de Moura
- Senne, Carlos
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