Risk factors for postoperative pulmonary complications in patients undergoing thoracotomy for indications other than primary lung cancer resection: a multicenter retrospective cohort study from the German thorax registry
Abstract: Background: Postoperative pulmonary complications (PPCs) are the most common complications following lung surgery and can lead to increased postoperative mortality. In this study, we examined the incidence of PPCs, the in-hospital mortality rate, and the risk factors associated with PPCs in patients undergoing open thoracotomy lung resection (OTLR) for reasons other than primary lung cancer. Methods: Data from this multicenter, retrospective study involving 1.368 patients were extracted from the German Thorax Registry and analyzed using univariate and multivariable statistical methods. Results: In total, 278 patients showed at least one PPC. The presence of PPCs was associated with a significantly higher in-hospital mortality rate (7.2% vs. 1.5%; p = 0.000). Multivariable stepwise logistic regression analysis showed absolute age (OR 1.02) and BMI ≤ 19 (OR 2.6) as independent patient-specific risk factors. Significant preoperative risk factors included re-thoracotomy (OR 4.0) and FEV1 < 60% (OR 2.5). Procedure-related independent risk factors for PPCs included a surgical duration surpassing 195 min (OR 2.7), the continuation of invasive ventilation post-surgery (OR 3.8), and an intraoperative infusion of crystalloids greater than 6 mL/kg/h (OR 1.8). Conclusions: Optimizing intraoperative fluid therapy and on-table extubation when possible may reduce the incidence of PPCs and associated mortality
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Notes
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Journal of clinical medicine. - 14, 5 (2025) , 1565, ISSN: 2077-0383
- Classification
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Medizin, Gesundheit
- Event
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Veröffentlichung
- (where)
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Freiburg
- (who)
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Universität
- (when)
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2025
- Creator
- DOI
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10.3390/jcm14051565
- URN
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urn:nbn:de:bsz:25-freidok-2635415
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:31 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
Time of origin
- 2025
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Bilateral staged thoracotomy for multiple lung hydatidosis
Surgical repair via submammary thoracotomy, right axillary thoracotomy and median sternotomy for ventricular septal defects
Techniques for thoracic duct cannulation without thoracotomy in piglets
Chronic pain in thoracotomy
Indications and techniques for laparoscopy
Outcomes following resuscitative thoracotomy for abdominal exsanguination, a systematic review
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Blunt Chest Trauma in Polytraumatized Patients: Predictive Factors for Urgent Thoracotomy
Partial cardiopulmonary bypass through left thoracotomy for coarctation repair in children
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Risk factors for postoperative pulmonary complications leading to increased in-hospital mortality in patients undergoing thoracotomy for primary lung cancer resection: a multicentre retrospective cohort study of the German thorax registry
Bilateral staged thoracotomy for multiple lung hydatidosis
Surgical repair via submammary thoracotomy, right axillary thoracotomy and median sternotomy for ventricular septal defects
Techniques for thoracic duct cannulation without thoracotomy in piglets
Chronic pain in thoracotomy
Indications and techniques for laparoscopy
Outcomes following resuscitative thoracotomy for abdominal exsanguination, a systematic review
Outcomes and indications for emergency thoracotomy after adoption of a more liberal policy in a western European level 1 trauma centre: 8-year experience
Diagnostic reference levels and median doses for common clinical indications of CT: findings from an international registry
Blunt Chest Trauma in Polytraumatized Patients: Predictive Factors for Urgent Thoracotomy