Inhibition of transcription by dactinomycin reveals a new characteristic of immunogenic cell stress
Abstract: Chemotherapy still constitutes the standard of care for the treatment of most neoplastic diseases. Certain chemotherapeutics from the oncological armamentarium are able to trigger pre‐mortem stress signals that lead to immunogenic cell death (ICD), thus inducing an antitumor immune response and mediating long‐term tumor growth reduction. Here, we used an established model, built on artificial intelligence to identify, among a library of 50,000 compounds, anticancer agents that, based on their molecular descriptors, were predicted to induce ICD. This algorithm led us to the identification of dactinomycin (DACT, best known as actinomycin D), a highly potent cytotoxicant and ICD inducer that mediates immune‐dependent anticancer effects in vivo. Since DACT is commonly used as an inhibitor of DNA to RNA transcription, we investigated whether other experimentally established or algorithm‐selected, clinically employed ICD inducers would share this characteristic. As a common leitmotif, a panel of pharmacological ICD stimulators inhibited transcription and secondarily translation. These results establish the inhibition of RNA synthesis as an initial event for ICD induction.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Inhibition of transcription by dactinomycin reveals a new characteristic of immunogenic cell stress ; volume:12 ; number:5 ; year:2020 ; extent:22
EMBO molecular medicine / European Molecular Biology Organization ; 12, Heft 5 (2020) (gesamt 22)
- Urheber
-
Humeau, Juliette
Sauvat, Allan
Cerrato, Giulia
Xie, Wei
Loos, Friedemann
Iannantuoni, Francesca
Bezu, Lucillia
Lévesque, Sarah
Paillet, Juliette
Pol, Jonathan
Leduc, Marion
Zitvogel, Laurence
de Thé, Hugues
Kepp, Oliver
Kroemer, Guido
- DOI
-
10.15252/emmm.201911622
- URN
-
urn:nbn:de:101:1-2022062410411257344931
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:33 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Humeau, Juliette
- Sauvat, Allan
- Cerrato, Giulia
- Xie, Wei
- Loos, Friedemann
- Iannantuoni, Francesca
- Bezu, Lucillia
- Lévesque, Sarah
- Paillet, Juliette
- Pol, Jonathan
- Leduc, Marion
- Zitvogel, Laurence
- de Thé, Hugues
- Kepp, Oliver
- Kroemer, Guido
Ähnliche Objekte (12)
Loss minimizing strategy of permanent magnet synchronous machines using improved direct torque and flux control
The methodological incompatibility between an innate grammar and a bottom-up approach
Cell adhesion molecules in Drosophila synapse development and function
A knowledge distillation based cross-modal learning framework for the lithium-ion battery state of health estimation
Understanding e-commerce customer behaviors to use drone delivery services: A privacy calculus view
State of health estimation of lithium-ion battery based on CNN–WNN–WLSTM
Changes of Population, Built-up Land, and Cropland Exposure to Natural Hazards in China from 1995 to 2015
Elastic proton-proton scattering at LHC energies in holographic QCD
Treatments for the Early-Stage Hepatocellular Carcinoma: Laparoscopic Liver Resection or Percutaneous Radiofrequency: How to Make a Decision?
Te-Pei Feng: a pioneer of neuromuscular physiology in China
Enhanced photocatalytic activity of Se-doped TiO2 under visible light irradiation
Arbuscular mycorrhiza improved drought tolerance of maize seedlings by altering photosystem II efficiency and the levels of key metabolites
Loss minimizing strategy of permanent magnet synchronous machines using improved direct torque and flux control
The methodological incompatibility between an innate grammar and a bottom-up approach
Cell adhesion molecules in Drosophila synapse development and function
A knowledge distillation based cross-modal learning framework for the lithium-ion battery state of health estimation
Understanding e-commerce customer behaviors to use drone delivery services: A privacy calculus view
State of health estimation of lithium-ion battery based on CNN–WNN–WLSTM
Changes of Population, Built-up Land, and Cropland Exposure to Natural Hazards in China from 1995 to 2015
Elastic proton-proton scattering at LHC energies in holographic QCD
Treatments for the Early-Stage Hepatocellular Carcinoma: Laparoscopic Liver Resection or Percutaneous Radiofrequency: How to Make a Decision?
Te-Pei Feng: a pioneer of neuromuscular physiology in China
Enhanced photocatalytic activity of Se-doped TiO2 under visible light irradiation
Arbuscular mycorrhiza improved drought tolerance of maize seedlings by altering photosystem II efficiency and the levels of key metabolites
Loss minimizing strategy of permanent magnet synchronous machines using improved direct torque and flux control
The methodological incompatibility between an innate grammar and a bottom-up approach
Cell adhesion molecules in Drosophila synapse development and function
A knowledge distillation based cross-modal learning framework for the lithium-ion battery state of health estimation
Understanding e-commerce customer behaviors to use drone delivery services: A privacy calculus view
State of health estimation of lithium-ion battery based on CNN–WNN–WLSTM
Changes of Population, Built-up Land, and Cropland Exposure to Natural Hazards in China from 1995 to 2015
Elastic proton-proton scattering at LHC energies in holographic QCD
Treatments for the Early-Stage Hepatocellular Carcinoma: Laparoscopic Liver Resection or Percutaneous Radiofrequency: How to Make a Decision?
Te-Pei Feng: a pioneer of neuromuscular physiology in China
Enhanced photocatalytic activity of Se-doped TiO2 under visible light irradiation