Macrophages and β‐cells are responsible for CXCR2‐mediated neutrophil infiltration of the pancreas during autoimmune diabetes
Abstract: Autoimmune type 1 diabetes (T1D) development results from the interaction between pancreatic β‐cells, and the innate and the adaptive immune systems culminating with the destruction of the insulin‐secreting β‐cells by autoreactive T cells. This diabetogenic course starts during the first postnatal weeks by the infiltration of the pancreatic islets by innate immune cells and particularly neutrophils. Here, we aim to determine the cellular and molecular mechanism leading to the recruitment of this neutrophils in the pancreatic islets of non‐obese diabetic (NOD) mice. Here, we show that neutrophil recruitment in the pancreatic islets is controlled by inflammatory macrophages and β‐cells themselves. Macrophages and β‐cells produce the chemokines CXCL1 and CXCL2, recruiting CXCR2‐expressing neutrophils from the blood to the pancreatic islets. We further show that pancreatic macrophages secrete IL‐1β‐inducing CXCR2 ligand production by the β‐cells. Finally, the blockade of neutrophil recruitment at early ages using CXCR2 antagonist dampens the diabetogenic T‐cell response and the later development of autoimmune diabetes, supporting the therapeutic potential of this approach.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Macrophages and β‐cells are responsible for CXCR2‐mediated neutrophil infiltration of the pancreas during autoimmune diabetes ; volume:6 ; number:8 ; year:2014 ; pages:1090-1104 ; extent:14
EMBO molecular medicine / European Molecular Biology Organization ; 6, Heft 8 (2014), 1090-1104 (gesamt 14)
- Creator
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Diana, Julien
Lehuen, Agnès
- DOI
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10.15252/emmm.201404144
- URN
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urn:nbn:de:101:1-2023011305050698888999
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:38 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Diana, Julien
- Lehuen, Agnès
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