Mosaic RBD Nanoparticles Elicit Protective Immunity Against Multiple Human Coronaviruses in Animal Models
Abstract: To combat SARS‐CoV‐2 variants and MERS‐CoV, as well as the potential re‐emergence of SARS‐CoV and spillovers of sarbecoviruses, which pose a significant threat to global public health, vaccines that can confer broad‐spectrum protection against betacoronaviruses (β‐CoVs) are urgently needed. A mosaic ferritin nanoparticle vaccine is developed that co‐displays the spike receptor‐binding domains of SARS‐CoV, MERS‐CoV, and SARS‐CoV‐2 Wild‐type (WT) strain and evaluated its immunogenicity and protective efficacy in mice and nonhuman primates. A low dose of 10 µg administered at a 21‐day interval induced a Th1‐biased immune response in mice and elicited robust cross‐reactive neutralizing antibody responses against a variety of β‐CoVs, including a series of SARS‐CoV‐2 variants. It is also able to effectively protect against challenges of SARS‐CoV, MERS‐CoV, and SARS‐CoV‐2 variants in not only young mice but also the more vulnerable mice through induction of long‐lived immunity. Together, these results suggest that this mosaic 3‐RBD nanoparticle has the potential to be developed as a pan‐β‐CoV vaccine.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Mosaic RBD Nanoparticles Elicit Protective Immunity Against Multiple Human Coronaviruses in Animal Models ; day:17 ; month:12 ; year:2023 ; extent:13
Advanced science ; (17.12.2023) (gesamt 13)
- Creator
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Zhang, Yanjun
Sun, Jing
Zheng, Jian
Li, Suxiang
Rao, Haiyue
Dai, Jun
Zhang, Zhaoyong
Wang, Yanqun
Liu, Donglan
Chen, Zhao
Ran, Wei
Zhu, Airu
Li, Fang
Yan, Qihong
Wang, Yiliang
Yu, Kuai
Zhang, Shengnan
Wang, Dong
Tang, Yanhong
Liu, Banghui
Cheng, Linling
Huo, Jiandong
Perlman, Stanley
Zhao, Jingxian
Zhao, Jincun
- DOI
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10.1002/advs.202303366
- URN
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urn:nbn:de:101:1-2023121814070910235015
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:26 AM CEST
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Associated
- Zhang, Yanjun
- Sun, Jing
- Zheng, Jian
- Li, Suxiang
- Rao, Haiyue
- Dai, Jun
- Zhang, Zhaoyong
- Wang, Yanqun
- Liu, Donglan
- Chen, Zhao
- Ran, Wei
- Zhu, Airu
- Li, Fang
- Yan, Qihong
- Wang, Yiliang
- Yu, Kuai
- Zhang, Shengnan
- Wang, Dong
- Tang, Yanhong
- Liu, Banghui
- Cheng, Linling
- Huo, Jiandong
- Perlman, Stanley
- Zhao, Jingxian
- Zhao, Jincun
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