Late onset multiple sclerosis: concerns in aging patients

to related objects

Abstract: Late onset multiple sclerosis (LOMS) is when the first symptom starts after 50 years of age, representing 4.5% of multiple sclerosis (MS) patients. This study describes the clinical characteristics of patients with LOMS followed at a specialized MS center in São Paulo. Data was obtained from medical records of 742 patients with MS. The LOMS frequency was 4.18%, median age at onset was 54 years and the predominant disease course was primary progressive (64.3%). The patients reached the disability landmarks of EDSS grades 3.0, 6.0 and 7.0 in the following proportion and time: EDSS 3.0: 77.42% of patients in 3.7 years; EDSS 6.0: 58.06% in 5.1 years and EDSS 7.0: 32.26% in 5.7 years. The comparative analysis with a matched control group of patients with early onset MS showed that late onset, associated with a progressive course, were predictors of reaching EDSS 3.0 and 6.0 in a shorter time.

Alternative title: Esclerose múltipla de início tardio: atenção a uma população que envelhece

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Late onset multiple sclerosis: concerns in aging patients ; volume:75 ; number:07 ; year:2017 ; pages:451-456
Arquivos de neuro-psiquiatria ; 75, Heft 07 (2017), 451-456

Contributor: Lotti, Claudia Beatriz de Campos
Oliveira, Acary Souza Bulle
Bichuetti, Denis Bernardi
Castro, Isac de
Oliveira, Enedina Maria Lobato

DOI: 10.1590/0004-282X20170070

URN: urn:nbn:de:101:1-2023101911312311013058

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 14.08.2025, 10:58 AM CEST

Data provider

This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.

Show original at data provider

Associated

Lotti, Claudia Beatriz de Campos
Oliveira, Acary Souza Bulle
Bichuetti, Denis Bernardi
Castro, Isac de
Oliveira, Enedina Maria Lobato

Other Objects (12)

CD4 T-cell aging exacerbates neuroinflammation in a late-onset mouse model of amyotrophic lateral sclerosis

Late-age onset systemic sclerosis—clinical and serological characteristics

Correction: Late-age onset systemic sclerosis—clinical and serological characteristics

Diagnostic Cerebrospinal Fluid Biomarker in Early and Late Onset Multiple Sclerosis

Incidence of late onset multiple sclerosis in Italy: a population-based study

Familial risk of early- and late-onset multiple sclerosis: a Swedish nationwide study

Late onset postpartum psychoses

The accelerated aging model reveals critical mechanisms of late-onset Parkinson’s disease

Early and late onset sepsis in late preterm infants

Aufsatz

Early predictors of late onset offenders

Late-onset Atopische Dermatitis und Hypogonadismus

Late-Onset Melorheostosis: A Case Report

CD4 T-cell aging exacerbates neuroinflammation in a late-onset mouse model of amyotrophic lateral sclerosis

Late-age onset systemic sclerosis—clinical and serological characteristics

Correction: Late-age onset systemic sclerosis—clinical and serological characteristics

Diagnostic Cerebrospinal Fluid Biomarker in Early and Late Onset Multiple Sclerosis

Incidence of late onset multiple sclerosis in Italy: a population-based study

Familial risk of early- and late-onset multiple sclerosis: a Swedish nationwide study

Late onset postpartum psychoses

The accelerated aging model reveals critical mechanisms of late-onset Parkinson’s disease

Early and late onset sepsis in late preterm infants

Aufsatz

Early predictors of late onset offenders

Late-onset Atopische Dermatitis und Hypogonadismus

Late-Onset Melorheostosis: A Case Report

CD4 T-cell aging exacerbates neuroinflammation in a late-onset mouse model of amyotrophic lateral sclerosis

Late-age onset systemic sclerosis—clinical and serological characteristics

Correction: Late-age onset systemic sclerosis—clinical and serological characteristics

Diagnostic Cerebrospinal Fluid Biomarker in Early and Late Onset Multiple Sclerosis

Incidence of late onset multiple sclerosis in Italy: a population-based study

Familial risk of early- and late-onset multiple sclerosis: a Swedish nationwide study

Late onset postpartum psychoses

The accelerated aging model reveals critical mechanisms of late-onset Parkinson’s disease

Early and late onset sepsis in late preterm infants

Aufsatz

Early predictors of late onset offenders

Late-onset Atopische Dermatitis und Hypogonadismus

Late-Onset Melorheostosis: A Case Report

Cultural heritage institutions wishing to register will find more information here.

Fields marked * need to be filled in.

Username*

Please enter your username

Email*

Please enter your email address

Please do not fill this field

First name

Last name

Password*

Please enter your password

Confirm password*

Please enter the same password

I have read the terms of use and the privacy policy for the collection of personal data and accept them. *

This field is required.

I would like to subscribe to the newsletter of the Deutsche Digitale Bibliothek. See newsletter subscription info.

Account created

Your "My DDB" account has been successfully created. Before you can log in to your account, you must click the confirmation link in the message we just sent to the email address you provided.

Late onset multiple sclerosis: concerns in aging patients

Object Details

References and Relationships

Contributors, Places and Time

Further information

Data provider

Associated

Other Objects (12)

CD4 T-cell aging exacerbates neuroinflammation in a late-onset mouse model of amyotrophic lateral sclerosis

Late-age onset systemic sclerosis—clinical and serological characteristics

Correction: Late-age onset systemic sclerosis—clinical and serological characteristics

Diagnostic Cerebrospinal Fluid Biomarker in Early and Late Onset Multiple Sclerosis

Incidence of late onset multiple sclerosis in Italy: a population-based study

Familial risk of early- and late-onset multiple sclerosis: a Swedish nationwide study

Late onset postpartum psychoses

The accelerated aging model reveals critical mechanisms of late-onset Parkinson’s disease

Early and late onset sepsis in late preterm infants

Early predictors of late onset offenders

Late-onset Atopische Dermatitis und Hypogonadismus

Late-Onset Melorheostosis: A Case Report

CD4 T-cell aging exacerbates neuroinflammation in a late-onset mouse model of amyotrophic lateral sclerosis

Late-age onset systemic sclerosis—clinical and serological characteristics

Correction: Late-age onset systemic sclerosis—clinical and serological characteristics

Diagnostic Cerebrospinal Fluid Biomarker in Early and Late Onset Multiple Sclerosis

Incidence of late onset multiple sclerosis in Italy: a population-based study

Familial risk of early- and late-onset multiple sclerosis: a Swedish nationwide study

Late onset postpartum psychoses

The accelerated aging model reveals critical mechanisms of late-onset Parkinson’s disease

Early and late onset sepsis in late preterm infants

Early predictors of late onset offenders

Late-onset Atopische Dermatitis und Hypogonadismus

Late-Onset Melorheostosis: A Case Report

CD4 T-cell aging exacerbates neuroinflammation in a late-onset mouse model of amyotrophic lateral sclerosis

Late-age onset systemic sclerosis—clinical and serological characteristics

Correction: Late-age onset systemic sclerosis—clinical and serological characteristics

Diagnostic Cerebrospinal Fluid Biomarker in Early and Late Onset Multiple Sclerosis

Incidence of late onset multiple sclerosis in Italy: a population-based study

Familial risk of early- and late-onset multiple sclerosis: a Swedish nationwide study

Late onset postpartum psychoses

The accelerated aging model reveals critical mechanisms of late-onset Parkinson’s disease

Early and late onset sepsis in late preterm infants

Early predictors of late onset offenders

Late-onset Atopische Dermatitis und Hypogonadismus

Late-Onset Melorheostosis: A Case Report

Related objects

Reset password