Photosensitizer‐Amplified Antimicrobial Materials for Broad‐Spectrum Ablation of Resistant Pathogens in Ocular Infections
Abstract: The emergence of multidrug resistant (MDR) pathogens and the scarcity of new potent antibiotics and antifungals are one of the biggest threats to human health. Antimicrobial photodynamic therapy (aPDT) combines light and photosensitizers to kill drug‐resistant pathogens; however, there are limited materials that can effectively ablate different classes of infective pathogens. In the present work, a new class of benzodiazole‐paired materials is designed as highly potent PDT agents with broad‐spectrum antimicrobial activity upon illumination with nontoxic light. The results mechanistically demonstrate that the energy transfer and electron transfer between nonphotosensitive and photosensitive benzodiazole moieties embedded within pathogen‐binding peptide sequences result in increased singlet oxygen generation and enhanced phototoxicity. Chemical optimization renders PEP3 as a novel PDT agent with remarkable activity against MDR bacteria and fungi as well as pathogens at different stages of development (e.g., biofilms, spores, and fungal hyphae), which also prove effective in an ex vivo porcine model of microbial keratitis. The chemical modularity of this strategy and its general compatibility with peptide‐based targeting agents will accelerate the design of highly photosensitive materials for antimicrobial PDT.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Photosensitizer‐Amplified Antimicrobial Materials for Broad‐Spectrum Ablation of Resistant Pathogens in Ocular Infections ; day:27 ; month:05 ; year:2024 ; extent:18
Advanced materials ; (27.05.2024) (gesamt 18)
- Creator
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Lochenie, Charles
Duncan, Sheelagh
Zhou, Yanzi
Fingerhut, Leonie
Kiang, Alex
Benson, Sam
Jiang, Guanyu
Liu, Xiaogang
Mills, Bethany
Vendrell, Marc
- DOI
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10.1002/adma.202404107
- URN
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urn:nbn:de:101:1-2405271417119.347992832240
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:52 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Lochenie, Charles
- Duncan, Sheelagh
- Zhou, Yanzi
- Fingerhut, Leonie
- Kiang, Alex
- Benson, Sam
- Jiang, Guanyu
- Liu, Xiaogang
- Mills, Bethany
- Vendrell, Marc
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