Recovery of original individual person data (IPD) inferences from empirical IPD summaries only: applications to distributed computing under disclosure constraints

Abstract: There are many settings where individual person data (IPD) are not available, due to privacy or technical reasons, and one must work with IPD proxies, such as summary statistics, to approximate original IPD inferences, that is, the results of statistical analyses that would ideally have been performed on individual‐level data. For instance, in a distributed computing setting, as implemented in the DataSHIELD software framework, different centers can only share IPD proxies to obtain pooled IPD inferences. Such privacy requirements limit the scope of statistical investigation. For example, it can be challenging to perform between‐center random‐effect regression models. To increase modeling freedom we propose a method that only uses simple nondisclosive summaries of the original IPD as input, such as empirical marginal moments and correlation matrices, and generates artificial data compatible with those summary features. Specifically, data are generated from a Gaussian copula with marginal and joint components specified by the above summaries. The goal is to reproduce original IPD features in the artificial data, such that original IPD inferences are recovered from the artificial data. In an application example, and through simulations, we show that we can recover estimates of a multivariable IPD random‐effect logistic regression, from artificial data generated via the Gaussian copula using the above IPD summaries, suggesting the proposed approach provides a generally applicable strategy for distributed computing settings with data protection constraints

Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch
Notes
Statistics in medicine. - 39, 8 (2020) , 1183-1198, ISSN: 1097-0258

Keyword
Kopula

Event
Veröffentlichung
(where)
Freiburg
(who)
Universität
(when)
2020

DOI
10.1002/sim.8470
URN
urn:nbn:de:bsz:25-freidok-1551126
Rights
Der Zugriff auf das Objekt ist unbeschränkt möglich.
Last update
25.03.2025, 1:48 PM CET

Data provider

This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.

Associated

Time of origin

  • 2020

Other Objects (12)