Progranulin haploinsufficiency mediates cytoplasmic TDP-43 aggregation with lysosomal abnormalities in human microglia

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Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: 1 Online-Ressource.

Language: Englisch

Bibliographic citation: Progranulin haploinsufficiency mediates cytoplasmic TDP-43 aggregation with lysosomal abnormalities in human microglia ; volume:21 ; number:1 ; day:13 ; month:2 ; year:2024 ; pages:1-20 ; date:12.2024
Journal of neuroinflammation ; 21, Heft 1 (13.2.2024), 1-20, 12.2024

Creator: Sung, Wonjae
Noh, Min-Young
Nahm, Minyeop
Kim, Yong Sung
Ki, Chang-Seok
Kim, Young-Eun
Kim, Hee-Jin
Kim, Seung Hyun

Contributor: SpringerLink (Online service)

DOI: 10.1186/s12974-024-03039-1

URN: urn:nbn:de:101:1-2404220916285.968185829176

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 30.03.0137, 10:02 AM CET

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Sung, Wonjae
Noh, Min-Young
Nahm, Minyeop
Kim, Yong Sung
Ki, Chang-Seok
Kim, Young-Eun
Kim, Hee-Jin
Kim, Seung Hyun
SpringerLink (Online service)

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Lysosomal processing of progranulin

Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency

Progranulin and TDP-43: Mechanistic Links and Future Directions

Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency

The lysosomal protein cathepsin L is a progranulin protease

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Progranulin reduces insoluble TDP-43 levels, slows down axonal degeneration and prolongs survival in mutant TDP-43 mice

Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice

Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice

Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons

Caspase-4 mediates cytoplasmic accumulation of TDP-43 in the primate brains

Correction: Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons

Lysosomal processing of progranulin

Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency

Progranulin and TDP-43: Mechanistic Links and Future Directions

Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency

The lysosomal protein cathepsin L is a progranulin protease

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Progranulin reduces insoluble TDP-43 levels, slows down axonal degeneration and prolongs survival in mutant TDP-43 mice

Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice

Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice

Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons

Caspase-4 mediates cytoplasmic accumulation of TDP-43 in the primate brains

Correction: Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons

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Progranulin haploinsufficiency mediates cytoplasmic TDP-43 aggregation with lysosomal abnormalities in human microglia

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Other Objects (12)

Lysosomal processing of progranulin

Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency

Progranulin and TDP-43: Mechanistic Links and Future Directions

Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency

The lysosomal protein cathepsin L is a progranulin protease

Lysosomal dysfunction and microglial hyperactivation in models of progranulin deficiency

Progranulin reduces insoluble TDP-43 levels, slows down axonal degeneration and prolongs survival in mutant TDP-43 mice

Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice

Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice

Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons

Caspase-4 mediates cytoplasmic accumulation of TDP-43 in the primate brains

Correction: Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons

Lysosomal processing of progranulin

Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency

Progranulin and TDP-43: Mechanistic Links and Future Directions

Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency

The lysosomal protein cathepsin L is a progranulin protease

Lysosomal dysfunction and microglial hyperactivation in models of progranulin deficiency

Progranulin reduces insoluble TDP-43 levels, slows down axonal degeneration and prolongs survival in mutant TDP-43 mice

Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice

Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice

Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons

Caspase-4 mediates cytoplasmic accumulation of TDP-43 in the primate brains

Correction: Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons

Lysosomal processing of progranulin

Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency

Progranulin and TDP-43: Mechanistic Links and Future Directions

Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency

The lysosomal protein cathepsin L is a progranulin protease

Lysosomal dysfunction and microglial hyperactivation in models of progranulin deficiency

Progranulin reduces insoluble TDP-43 levels, slows down axonal degeneration and prolongs survival in mutant TDP-43 mice

Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice

Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice

Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons

Caspase-4 mediates cytoplasmic accumulation of TDP-43 in the primate brains

Correction: Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons

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