Progranulin haploinsufficiency mediates cytoplasmic TDP-43 aggregation with lysosomal abnormalities in human microglia
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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1 Online-Ressource.
- Sprache
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Englisch
- Erschienen in
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Progranulin haploinsufficiency mediates cytoplasmic TDP-43 aggregation with lysosomal abnormalities in human microglia ; volume:21 ; number:1 ; day:13 ; month:2 ; year:2024 ; pages:1-20 ; date:12.2024
Journal of neuroinflammation ; 21, Heft 1 (13.2.2024), 1-20, 12.2024
- Urheber
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Sung, Wonjae
Noh, Min-Young
Nahm, Minyeop
Kim, Yong Sung
Ki, Chang-Seok
Kim, Young-Eun
Kim, Hee-Jin
Kim, Seung Hyun
- Beteiligte Personen und Organisationen
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SpringerLink (Online service)
- DOI
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10.1186/s12974-024-03039-1
- URN
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urn:nbn:de:101:1-2404220916285.968185829176
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 11:02 MESZ
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Beteiligte
- Sung, Wonjae
- Noh, Min-Young
- Nahm, Minyeop
- Kim, Yong Sung
- Ki, Chang-Seok
- Kim, Young-Eun
- Kim, Hee-Jin
- Kim, Seung Hyun
- SpringerLink (Online service)
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Progranulin reduces insoluble TDP-43 levels, slows down axonal degeneration and prolongs survival in mutant TDP-43 mice
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Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency
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Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency
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Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice
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