Deoxybouvardin-glucoside induces apoptosis in non-small cell lung cancer cells by targeting EGFR/MET and AKT signaling pathway
Abstract: Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related deaths worldwide. Its treatment is complicated due to the development of resistance to conventional chemotherapy and targeted therapy. Deoxybouvardin and related cyclic hexapeptides reportedly exhibit antitumor activities, but their mechanisms of action remain unclear. This study aimed to investigate the anticancer mechanisms of deoxybouvardin glucoside (DBG), a glucosidic form of deoxybouvardin from Rubia species, in gefitinib (GEF)-sensitive and -resistant NSCLC HCC827 cells. The effects of DBG treatment on cell proliferation were evaluated using a viability assay. The inhibitory effects of DBG treatment on the activities and phosphorylation of the protein kinases epidermal growth factor receptor (EGFR), MET, and AKTs were assessed using in vitro kinase assay and western blot, respectively. DBG treatment inhibited the growth of HCC827 cells in a concentration- and time-dependent manner. Results of in vitro ki.... https://www.excli.de/excli/article/view/7359
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Deoxybouvardin-glucoside induces apoptosis in non-small cell lung cancer cells by targeting EGFR/MET and AKT signaling pathway ; volume:23 ; year:2024
EXCLI journal ; 23 (2024)
- Creator
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Lee, Na Yeong
Joo, Sang Hoon
Nam, A-Young
Lee, Seung-On
Yoon, Goo
Cho, Seung-sik
Choi, Yung Hyun
Park, Jin Woo
Shim, Jung-Hyun
- DOI
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10.17179/excli2024-7359
- URN
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urn:nbn:de:101:1-2411080213377.337928921931
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:38 AM CEST
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Associated
- Lee, Na Yeong
- Joo, Sang Hoon
- Nam, A-Young
- Lee, Seung-On
- Yoon, Goo
- Cho, Seung-sik
- Choi, Yung Hyun
- Park, Jin Woo
- Shim, Jung-Hyun
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