L-rhamnose and L-fucose suppress cancer growth in mice

Abstract: It is documented that deficient fucosylation may play an important role in the pathogenesis of cancer. Since the supplementation of L-fucose could restore fucosylation in both in vitro and in vivo conditions, our intent was to examine the effect of intraperitoneal administration of L-fucose and L-rhamnose (a similar deoxysaccharide) on tumour growth, mitotic activity and metastatic setting of a solid form of Ehrlich carcinoma as well as on the survival rate of tumour bearing mice. Both L-fucose and L-rhamnose exerted a significant suppressive effect on tumour growth (P<0.05). After 10 days of therapy, the greatest inhibition of tumour growth expressed as a percentage of controls was observed in L-rhamnose at a dose of 3 g/kg/day (by 62%) and L-fucose at a dose of 5 g/kg/day (by 47%). Moreover, the mitotic index decreased with increasing doses of L-fucose and L-rhamnose. Prolonged survival of tumour bearing mice was observed after 14 consecutive days of daily administering L-rhamnose. Its optimal dose was estimated to be 3.64 g/kg/day. L-Fucose, however, displayed only a slight effect on the survival of the mice. Our results suggest that L-fucose and especially L-rhamnose have anticancer potential. This study is the first to demonstrate the tumour-inhibitory effect of L-rhamnose.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: L-rhamnose and L-fucose suppress cancer growth in mice ; volume:6 ; number:1 ; year:2011 ; pages:1-9 ; extent:9 ; Open life sciences ; 6, Heft 1 (2011), 1-9 (gesamt 9)

Beteiligte, Orts- und Zeitangaben

• Urheber: Tomsik, Pavel ; Soukup, Tomas ; Cermakova, Eva ; Micuda, Stanislav ; Niang, Mohamed ; Sucha, Lenka ; Rezacova, Martina

Weitere Informationen

• DOI: 10.2478/s11535-010-0087-0
• URN: urn:nbn:de:101:1-2409201839371.498621287578
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 19.03.2096, 00:00 MEZ