Neurotransmitters: potential targets in glioblastoma
Abstract: For decades, glioblastoma multiforme (GBM), a type of the most lethal brain tumor, has remained a formidable challenge in terms of its treatment. Recently, many novel discoveries have underlined the regulatory roles of neurotransmitters in the microenvironment both physiologically and pathologically. By targeting the receptors synaptically or non-synaptically, neurotransmitters activate multiple signaling pathways. Significantly, many ligands acting on neurotransmitter receptors have shown great potential for inhibiting GBM growth and development, requiring further research. Here, we provide an overview of the most novel advances concerning the role of neurotransmitters in the normal neural and the GBM microenvironments, and discuss potential targeted drugs used for GBM treatment
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Anmerkungen
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Cancers. - 14, 16 (2022) , 3970, ISSN: 2072-6694
- Ereignis
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Veröffentlichung
- (wo)
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Freiburg
- (wer)
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Universität
- (wann)
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2022
- Urheber
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Huang, Qiqi
Chen, Lishi
Liang, Jianhao
Huang, Qiongzhen
Sun, Haitao
- DOI
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10.3390/cancers14163970
- URN
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urn:nbn:de:bsz:25-freidok-2290226
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:36 MESZ
Datenpartner
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Beteiligte
- Huang, Qiqi
- Chen, Lishi
- Liang, Jianhao
- Huang, Qiongzhen
- Sun, Haitao
- Universität
Entstanden
- 2022
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