Dissipative Control over the Toehold‐Mediated DNA Strand Displacement Reaction

to related objects

Abstract: Here we show a general approach to achieve dissipative control over toehold‐mediated strand‐displacement, the most widely employed reaction in the field of DNA nanotechnology. The approach relies on rationally re‐engineering the classic strand displacement reaction such that the high‐energy invader strand (fuel) is converted into a low‐energy waste product through an energy‐dissipating reaction allowing the spontaneous return to the original state over time. We show that such dissipative control over the toehold‐mediated strand displacement process is reversible (up to 10 cycles), highly controllable and enables unique temporal activation of DNA systems. We show here two possible applications of this strategy: the transient labelling of DNA structures and the additional temporal control of cascade reactions.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Dissipative Control over the Toehold‐Mediated DNA Strand Displacement Reaction ; day:05 ; month:04 ; year:2022 ; extent:1
Angewandte Chemie / International edition. International edition ; (05.04.2022) (gesamt 1)

Creator: Del Grosso, Erica
Irmisch, Patrick
Gentile, Serena
Prins, Leonard J.
Seidel, Ralf
Ricci, Francesco

DOI: 10.1002/anie.202201929

URN: urn:nbn:de:101:1-2022040515344481203437

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 08.08.2025, 6:18 AM CEST

Data provider

This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.

Show original at data provider

Associated

Del Grosso, Erica
Irmisch, Patrick
Gentile, Serena
Prins, Leonard J.
Seidel, Ralf
Ricci, Francesco

Other Objects (12)

Dissipative Control over the Toehold‐Mediated DNA Strand Displacement Reaction

Dissipative Control over the Toehold‐Mediated DNA Strand Displacement Reaction

Single-molecule force spectroscopy of toehold-mediated strand displacement

Single-molecule force spectroscopy of toehold-mediated strand displacement

Three-input logic gate based on DNA strand displacement reaction

Three-input logic gate based on DNA strand displacement reaction

Employing toehold-mediated DNA strand displacement reactions for biomedical applications

Employing toehold-mediated DNA strand displacement reactions for biomedical applications

Toehold-Mediated Strand Displacement in RNA-Based Molecular Switches and Gene Regulation

Toehold-Mediated Strand Displacement in RNA-Based Molecular Switches and Gene Regulation

Dissipative solitons in reaction diffusion systems : mechanisms, dynamics, interaction

Dissipative solitons in reaction diffusion systems : mechanisms, dynamics, interaction

Self-selection of dissipative assemblies driven by primitive chemical reaction networks

Self-selection of dissipative assemblies driven by primitive chemical reaction networks

Dissipative solitons

Dissipative solitons

Dissipative tunneling

Dissipative tunneling

Development of Dissipative Out-of-Equilibrium Materials from Direct Chemical Reaction Cycles

Development of Dissipative Out-of-Equilibrium Materials from Direct Chemical Reaction Cycles

Dissipative Cyclic Reaction Networks: Mechanistic Insights into a Minor Enantiomer Recycling Process

Dissipative Cyclic Reaction Networks: Mechanistic Insights into a Minor Enantiomer Recycling Process

A dissipative finite volume scheme for reaction-diffusion systems in heterogeneous materials

Hochschulschrift

A dissipative finite volume scheme for reaction-diffusion systems in heterogeneous materials

Dissipative Control over the Toehold‐Mediated DNA Strand Displacement Reaction

Dissipative Control over the Toehold‐Mediated DNA Strand Displacement Reaction

Single-molecule force spectroscopy of toehold-mediated strand displacement

Single-molecule force spectroscopy of toehold-mediated strand displacement

Three-input logic gate based on DNA strand displacement reaction

Three-input logic gate based on DNA strand displacement reaction

Employing toehold-mediated DNA strand displacement reactions for biomedical applications

Employing toehold-mediated DNA strand displacement reactions for biomedical applications

Toehold-Mediated Strand Displacement in RNA-Based Molecular Switches and Gene Regulation

Toehold-Mediated Strand Displacement in RNA-Based Molecular Switches and Gene Regulation

Dissipative solitons in reaction diffusion systems : mechanisms, dynamics, interaction

Dissipative solitons in reaction diffusion systems : mechanisms, dynamics, interaction

Self-selection of dissipative assemblies driven by primitive chemical reaction networks

Self-selection of dissipative assemblies driven by primitive chemical reaction networks

Dissipative solitons

Dissipative solitons

Dissipative tunneling

Dissipative tunneling

Development of Dissipative Out-of-Equilibrium Materials from Direct Chemical Reaction Cycles

Development of Dissipative Out-of-Equilibrium Materials from Direct Chemical Reaction Cycles

Dissipative Cyclic Reaction Networks: Mechanistic Insights into a Minor Enantiomer Recycling Process

Dissipative Cyclic Reaction Networks: Mechanistic Insights into a Minor Enantiomer Recycling Process

A dissipative finite volume scheme for reaction-diffusion systems in heterogeneous materials

Hochschulschrift

A dissipative finite volume scheme for reaction-diffusion systems in heterogeneous materials

Dissipative Control over the Toehold‐Mediated DNA Strand Displacement Reaction

Dissipative Control over the Toehold‐Mediated DNA Strand Displacement Reaction

Single-molecule force spectroscopy of toehold-mediated strand displacement

Single-molecule force spectroscopy of toehold-mediated strand displacement

Three-input logic gate based on DNA strand displacement reaction

Three-input logic gate based on DNA strand displacement reaction

Employing toehold-mediated DNA strand displacement reactions for biomedical applications

Employing toehold-mediated DNA strand displacement reactions for biomedical applications

Toehold-Mediated Strand Displacement in RNA-Based Molecular Switches and Gene Regulation

Toehold-Mediated Strand Displacement in RNA-Based Molecular Switches and Gene Regulation

Dissipative solitons in reaction diffusion systems : mechanisms, dynamics, interaction

Dissipative solitons in reaction diffusion systems : mechanisms, dynamics, interaction

Self-selection of dissipative assemblies driven by primitive chemical reaction networks

Self-selection of dissipative assemblies driven by primitive chemical reaction networks

Dissipative solitons

Dissipative solitons

Dissipative tunneling

Dissipative tunneling

Development of Dissipative Out-of-Equilibrium Materials from Direct Chemical Reaction Cycles

Development of Dissipative Out-of-Equilibrium Materials from Direct Chemical Reaction Cycles

Dissipative Cyclic Reaction Networks: Mechanistic Insights into a Minor Enantiomer Recycling Process

Dissipative Cyclic Reaction Networks: Mechanistic Insights into a Minor Enantiomer Recycling Process

A dissipative finite volume scheme for reaction-diffusion systems in heterogeneous materials

Hochschulschrift

A dissipative finite volume scheme for reaction-diffusion systems in heterogeneous materials

Cultural heritage institutions wishing to register will find more information here.

Fields marked * need to be filled in.

Username*

Please enter your username

Email*

Please enter your email address

Please do not fill this field

First name

Last name

Password*

Please enter your password

Confirm password*

Please enter the same password

I have read the terms of use and the privacy policy for the collection of personal data and accept them. *

This field is required.

I would like to subscribe to the newsletter of the Deutsche Digitale Bibliothek. See newsletter subscription info.

Account created

Your "My DDB" account has been successfully created. Before you can log in to your account, you must click the confirmation link in the message we just sent to the email address you provided.