Fast-track neuropathological screening for neurodegenerative diseases

Abstract: Background: The postmortem diagnostic of individuals having suffered presumptive neurodegenerative disease comprises exclusion of a prion disease, extensive brain sampling and histopathological evaluation, which are resource-intensive and time consuming. To exclude prion disease and to achieve prompt accurate preliminary diagnosis, we developed a fast-track procedure for the histopathological assessment of brains from patients with suspected neurodegenerative disease. Methods: Based on the screening of two brain regions (frontal cortex and cerebellum) with H&E and six immunohistochemical stainings in 133 brain donors, a main histopathological diagnosis was established and compared to the final diagnosis made after a full histopathological work-up according to our brain bank standard procedure. Results: In over 96 % of cases there was a concordance between the fast-track and the final main neuropathological diagnosis. A prion disease was identified in four cases without prior clinic.... https://www.uni-muenster.de/Ejournals/index.php/fnp/article/view/5643

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Fast-track neuropathological screening for neurodegenerative diseases ; volume:5 ; year:2024 ; Free Neuropathology ; 5 (2024)

Contributors, Places and Time

• Creator: Englert, Benjamin ; Roeber, Sigrun ; Arzberger, Thomas ; Ruf, Viktoria ; Windl, Otto ; Herms, Jochen

Further information

• DOI: 10.17879/freeneuropathology-2024-5643
• URN: urn:nbn:de:hbz:6:3-freeneuropathology-2024-59065
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:37 AM CEST