Colonic Dilatation Complicating Acute Severe Ulcerative Colitis Managed Successfully with Accelerated Infliximab Dosing
Lately, emerging data suggest an association between the development of inflammatory bowel disease and anti-interleukin-17 therapy. Megacolon is a life-threatening complication of acute severe ulcerative colitis (ASUC), but its treatment has not yet been established in current practice guidelines. We report a rare case of known psoriasis treated by secukinumab in a patient who presented with ASUC and colonic dilatation. Neither steroids nor standard infliximab regimen was effective. Finally, rescue therapy with accelerated infliximab strategy resulted in excellent recovery. In certain cases of steroid-refractory ASUC complicated by megacolon, accelerated infliximab regimen can be an alternative to surgery.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Colonic Dilatation Complicating Acute Severe Ulcerative Colitis Managed Successfully with Accelerated Infliximab Dosing ; volume:17 ; number:1 ; year:2023 ; pages:82-88 ; extent:7
Case reports in gastroenterology ; 17, Heft 1 (2023), 82-88 (gesamt 7)
- Urheber
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Bui, Hoang Huu
Dang, Luan Minh
Vo, Diem Thi-Ngoc
Nguyen, Chuong Dinh
- DOI
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10.1159/000529152
- URN
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urn:nbn:de:101:1-2024010323384650990545
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:25 MESZ
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Beteiligte
- Bui, Hoang Huu
- Dang, Luan Minh
- Vo, Diem Thi-Ngoc
- Nguyen, Chuong Dinh
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