Subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice
Abstract: The hippocampus is the brain’s center for episodic memories. Its subregions, the dentate gyrus and CA1-3, are differentially involved in memory encoding and recall. Hippocampal principal cells represent episodic features like movement, space, and context, but less is known about GABAergic interneurons. Here, we performed two-photon calcium imaging of parvalbumin- and somatostatin-expressing interneurons in the dentate gyrus and CA1-3 of male mice exploring virtual environments. Parvalbumin-interneurons increased activity with running-speed and reduced it in novel environments. Somatostatin-interneurons in CA1-3 behaved similar to parvalbumin-expressing cells, but their dentate gyrus counterparts increased activity during rest and in novel environments. Congruently, chemogenetic silencing of dentate parvalbumin-interneurons had prominent effects in familiar contexts, while silencing somatostatin-expressing cells increased similarity of granule cell representations between novel and familiar environments. Our data indicate unique roles for parvalbumin- and somatostatin-positive interneurons in the dentate gyrus that are distinct from those in CA1-3 and may support routing of novel information
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Notes
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Nature Communications. - 15, 1 (2024) , 714, ISSN: 2041-1723
- Classification
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Medizin, Gesundheit
- Event
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Veröffentlichung
- (where)
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Freiburg
- (who)
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Universität
- (when)
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2024
- Creator
- DOI
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10.1038/s41467-024-44882-3
- URN
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urn:nbn:de:bsz:25-freidok-2439291
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:47 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Hainmüller, Thomas
- Cazala, Aurore
- Huang, Li-Wen
- Bartos, Marlene
- Universität
Time of origin
- 2024
Other Objects (12)
Subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice
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Effect of Neuromodulation of Short-term Plasticity on Information Processing in Hippocampal Interneuron Synapses
Discrete subicular circuits control generalization of hippocampal seizures
Govern, Peter
Novelty triggers time-dependent theta oscillatory dynamics in cortical-hippocampal-midbrain circuitry
GABAerge und glutamaterge Modulation hemmender Interneuron-Interneuron-Synapsen im Hippokampus der Ratte
Characterizing the transient K+current contribution to subthreshold membrane potential oscillations in a hippocampal interneuron model
Consent to Govern
Last novelty
Subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice
Modular interneuron circuits control motion sensitivity in the mouse retina
Conserved behavioral circuits govern high-speed decision-making in wild fish shoals
Asynchronous GABA release generates long-lasting inhibition at a hippocampal interneuron-principal neuron synapse
Effect of Neuromodulation of Short-term Plasticity on Information Processing in Hippocampal Interneuron Synapses
Discrete subicular circuits control generalization of hippocampal seizures
Govern, Peter
Novelty triggers time-dependent theta oscillatory dynamics in cortical-hippocampal-midbrain circuitry
GABAerge und glutamaterge Modulation hemmender Interneuron-Interneuron-Synapsen im Hippokampus der Ratte
Characterizing the transient K+current contribution to subthreshold membrane potential oscillations in a hippocampal interneuron model
Consent to Govern
Last novelty
Subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice
Modular interneuron circuits control motion sensitivity in the mouse retina
Conserved behavioral circuits govern high-speed decision-making in wild fish shoals
Asynchronous GABA release generates long-lasting inhibition at a hippocampal interneuron-principal neuron synapse
Effect of Neuromodulation of Short-term Plasticity on Information Processing in Hippocampal Interneuron Synapses
Discrete subicular circuits control generalization of hippocampal seizures
Govern, Peter
Novelty triggers time-dependent theta oscillatory dynamics in cortical-hippocampal-midbrain circuitry
GABAerge und glutamaterge Modulation hemmender Interneuron-Interneuron-Synapsen im Hippokampus der Ratte
Characterizing the transient K+current contribution to subthreshold membrane potential oscillations in a hippocampal interneuron model
Consent to Govern