Macula, choroid and retinal nerve fiber layer optical coherence tomography biomarkers in liver dysfunction

Objectives: We aimed on evaluating the effect of liver dysfunction on retinal nerve fiber layer (RNFL), GCL++ (ganglion cell layer + RNFL + inner plexiform layer), central macular thickness (CMT) and subfoveal choroidal thickness (CT) measurements. Methods: Fifty two patients with primary biliary cirrhosis (PBC group) and 61 healthy individuals (control group) were included in our study. Blood alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyltransferase (GGT), alkaline phosphatase (ALP), total bilirubin, albumin, prothrombin time results as the international normalized ratio (INR), neutrophil (NEUT), lymphocyte (LYMP), neutrophil lymphocyte rate (NLR), platelet (PLT), mean platelet volume (MPV) levels were analyzed in both groups. RNFL, Inferior RNFL (IRNFL), Superior RNFL (SRNFL), GCL++, CMT and CT were measured by swept source optical coherence tomography (OCT). The choroidal vascular index (CVI) was also obtained. Results: GGT (p=0.001), ALP (p<0.001), albumin (p<0.001), NEUT (p=0.046) and MPV (p<0.001) values were higher in the PBC group. INR (p=0.017) and PLT (p=0.027) values were lower in the PBC group. CMT (p=0.015), CT (p=0.002), and GCL++ (p<0.001) values were found lower in the PBC group. Conclusions: OCT analyzes revealed thinning in CMT, CT and GCL++ in patients with liver dysfunction. OCT analyzes should be evaluated during periodic ocular examinations of PBC patients.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Macula, choroid and retinal nerve fiber layer optical coherence tomography biomarkers in liver dysfunction ; volume:48 ; number:1 ; year:2022 ; pages:39-43 ; extent:05 ; Turkish journal of biochemistry ; 48, Heft 1 (2022), 39-43 (gesamt 05)

Beteiligte, Orts- und Zeitangaben

• Urheber: Zeki Fikret, Cenk ; Avci, Enver ; Ucgun, Nil İrem ; Yildirim, Busra ; Yildirim, Filiz ; Hamaci, Mevlut

Weitere Informationen

• DOI: 10.1515/tjb-2022-0064
• URN: urn:nbn:de:101:1-2023031513114785275725
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 14.08.2025, 10:56 MESZ