Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain

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Location: Deutsche Nationalbibliothek Frankfurt am Main

ISSN: 1750-1326

Extent: Online-Ressource

Language: Englisch

Notes: online resource.

Bibliographic citation: Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain ; volume:17 ; number:1 ; day:10 ; month:1 ; year:2022 ; pages:1-19 ; date:12.2022
Molecular neurodegeneration ; 17, Heft 1 (10.1.2022), 1-19, 12.2022

Creator: Xu, Enquan
Boddu, Ravindra
Abdelmotilib, Hisham A.
Sokratian, Arpine
Kelly, Kaela
Liu, Zhiyong
Bryant, Nicole
Chandra, Sidhanth
Carlisle, Samantha M.
Lefkowitz, Elliot J.
Harms, Ashley S.
Benveniste, Etty N.
Yacoubian, Talene A.
Volpicelli-Daley, Laura A.
Standaert, David G.
West, Andrew B.

Contributor: SpringerLink (Online service)

DOI: 10.1186/s13024-021-00509-5

URN: urn:nbn:de:101:1-2022042422372568532708

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:26 AM CEST

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Associated

Xu, Enquan
Boddu, Ravindra
Abdelmotilib, Hisham A.
Sokratian, Arpine
Kelly, Kaela
Liu, Zhiyong
Bryant, Nicole
Chandra, Sidhanth
Carlisle, Samantha M.
Lefkowitz, Elliot J.
Harms, Ashley S.
Benveniste, Etty N.
Yacoubian, Talene A.
Volpicelli-Daley, Laura A.
Standaert, David G.
West, Andrew B.
SpringerLink (Online service)

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Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain

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Other Objects (12)

LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation

Lipopolysaccharide inhalation recruits monocytes and dendritic cell subsets to the alveolar airspace

Leucine-rich repeat kinase 2 (LRRK2) regulates α-synuclein clearance in microglia

LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons

Glucocorticoids promote apoptosis of proinflammatory monocytes by inhibiting ERK activity

LRRK2 interactions with α-synuclein in Parkinson’s disease brains and in cell models

Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein

Human Microglia–Like Cells Differentiated from Monocytes with GM-CSF and IL-34 Show Phagocytosis of α-Synuclein Aggregates and C/EBPβ-Dependent Proinflammatory Activation

Parkinson-causing mutations in LRRK2 impair the physiological tetramerization of endogenous α-synuclein in human neurons

Pro-inflammatory mediators released by activated monocytes promote aortic valve fibrocalcific activity

LXR Activation Induces a Proinflammatory Trained Innate Immunity-Phenotype in Human Monocytes

LRRK2 inhibition does not impart protection from α-synuclein pathology and neuron death in non-transgenic mice

LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation

Lipopolysaccharide inhalation recruits monocytes and dendritic cell subsets to the alveolar airspace

Leucine-rich repeat kinase 2 (LRRK2) regulates α-synuclein clearance in microglia

LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons

Glucocorticoids promote apoptosis of proinflammatory monocytes by inhibiting ERK activity

LRRK2 interactions with α-synuclein in Parkinson’s disease brains and in cell models

Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein

Human Microglia–Like Cells Differentiated from Monocytes with GM-CSF and IL-34 Show Phagocytosis of α-Synuclein Aggregates and C/EBPβ-Dependent Proinflammatory Activation

Parkinson-causing mutations in LRRK2 impair the physiological tetramerization of endogenous α-synuclein in human neurons

Pro-inflammatory mediators released by activated monocytes promote aortic valve fibrocalcific activity

LXR Activation Induces a Proinflammatory Trained Innate Immunity-Phenotype in Human Monocytes

LRRK2 inhibition does not impart protection from α-synuclein pathology and neuron death in non-transgenic mice

LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation

Lipopolysaccharide inhalation recruits monocytes and dendritic cell subsets to the alveolar airspace

Leucine-rich repeat kinase 2 (LRRK2) regulates α-synuclein clearance in microglia

LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons

Glucocorticoids promote apoptosis of proinflammatory monocytes by inhibiting ERK activity

LRRK2 interactions with α-synuclein in Parkinson’s disease brains and in cell models

Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein

Human Microglia–Like Cells Differentiated from Monocytes with GM-CSF and IL-34 Show Phagocytosis of α-Synuclein Aggregates and C/EBPβ-Dependent Proinflammatory Activation

Parkinson-causing mutations in LRRK2 impair the physiological tetramerization of endogenous α-synuclein in human neurons

Pro-inflammatory mediators released by activated monocytes promote aortic valve fibrocalcific activity

LXR Activation Induces a Proinflammatory Trained Innate Immunity-Phenotype in Human Monocytes

LRRK2 inhibition does not impart protection from α-synuclein pathology and neuron death in non-transgenic mice

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