A robust evaluation of TDP-43, poly GP, cellular pathology and behavior in an AAV-C9ORF72 (G4C2)66 mouse model

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Standort: Deutsche Nationalbibliothek Frankfurt am Main

Umfang: 1 Online-Ressource.

Sprache: Englisch

Erschienen in: A robust evaluation of TDP-43, poly GP, cellular pathology and behavior in an AAV-C9ORF72 (G4C2)66 mouse model ; volume:12 ; number:1 ; day:26 ; month:12 ; year:2024 ; pages:1-24 ; date:12.2024
Acta Neuropathologica Communications ; 12, Heft 1 (26.12.2024), 1-24, 12.2024

Urheber: Thompson, Emily G.
Spead, Olivia
Akerman, Suleyman C.
Curcio, Carrie
Zaepfel, Benjamin L.
Kent, Erica R.
Philips, Thomas
Vijayakumar, Balaji G.
Zacco, Anna
Zhou, Weibo
Nagappan, Guhan
Rothstein, Jeffrey D.

Beteiligte Personen und Organisationen: SpringerLink (Online service)

DOI: 10.1186/s40478-024-01911-y

URN: urn:nbn:de:101:1-2503052106509.087928106404

Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Letzte Aktualisierung: 15.08.2025, 07:25 MESZ

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Beteiligte

Thompson, Emily G.
Spead, Olivia
Akerman, Suleyman C.
Curcio, Carrie
Zaepfel, Benjamin L.
Kent, Erica R.
Philips, Thomas
Vijayakumar, Balaji G.
Zacco, Anna
Zhou, Weibo
Nagappan, Guhan
Rothstein, Jeffrey D.
SpringerLink (Online service)

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A robust evaluation of TDP-43, poly GP, cellular pathology and behavior in an AAV-C9ORF72 (G4C2)66 mouse model

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Ähnliche Objekte (12)

Poly-GA triggers TDP-43 pathology by inhibiting the proteasome and nucleocytoplasmic import in C9orf72 ALS/FTD

Validated assays for the quantification of C9orf72 human pathology

HR23B pathology preferentially co-localizes with p62, pTDP-43 and poly-GA in C9ORF72-linked frontotemporal dementia and amyotrophic lateral sclerosis

TDP-43 Pathology in Alzheimer’s Disease

Nucleolar stress in C9orf72 and sporadic ALS spinal motor neurons precedes TDP-43 mislocalization

Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy

Neuronal Expression of UBQLN2P497H Exacerbates TDP-43 Pathology in TDP-43G348C Mice through Interaction with Ubiquitin

Spreading of TDP-43 pathology via pyramidal tract induces ALS-like phenotypes in TDP-43 transgenic mice

Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology

TDP-43 pathology is associated with increased tau burdens and seeding

HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases

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Poly-GA triggers TDP-43 pathology by inhibiting the proteasome and nucleocytoplasmic import in C9orf72 ALS/FTD

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HR23B pathology preferentially co-localizes with p62, pTDP-43 and poly-GA in C9ORF72-linked frontotemporal dementia and amyotrophic lateral sclerosis

TDP-43 Pathology in Alzheimer’s Disease

Nucleolar stress in C9orf72 and sporadic ALS spinal motor neurons precedes TDP-43 mislocalization

Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy

Neuronal Expression of UBQLN2P497H Exacerbates TDP-43 Pathology in TDP-43G348C Mice through Interaction with Ubiquitin

Spreading of TDP-43 pathology via pyramidal tract induces ALS-like phenotypes in TDP-43 transgenic mice

Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology

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HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases

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HR23B pathology preferentially co-localizes with p62, pTDP-43 and poly-GA in C9ORF72-linked frontotemporal dementia and amyotrophic lateral sclerosis

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Nucleolar stress in C9orf72 and sporadic ALS spinal motor neurons precedes TDP-43 mislocalization

Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy

Neuronal Expression of UBQLN2P497H Exacerbates TDP-43 Pathology in TDP-43G348C Mice through Interaction with Ubiquitin

Spreading of TDP-43 pathology via pyramidal tract induces ALS-like phenotypes in TDP-43 transgenic mice

Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology

TDP-43 pathology is associated with increased tau burdens and seeding

HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases

In vivo staging of frontotemporal lobar degeneration TDP-43 type C pathology

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