Calumenin contributes to epithelial-mesenchymal transition and predicts poor survival in glioma
Background: Calumenin (CALU) has been reported to be associated with invasiveness and metastasis in some malignancies. However, in glioma, the role of CALU remains unclear. Methods: Clinical and transcriptome data of 998 glioma patients, including 301 from CGGA and 697 from TCGA dataset, were included. R language was used to perform statistical analyses. Results: CALU expression was significantly upregulated in more malignant gliomas, including higher grade, IDH wildtype, mesenchymal, and classical subtype. Gene Ontology analysis revealed that CALU-correlated genes were mainly enriched in cell/biological adhesion, response to wounding, and extracellular matrix/structure organization, all of which were strongly correlated with the epithelial-mesenchymal transition (EMT) phenotype. GSEA further validated the profound involvement of CALU in EMT. Subsequent GSVA suggested that CALU was particularly correlated with three EMT signaling pathways, including TGFβ, PI3K/AKT, and hypoxia pathway. Furthermore, CALU played synergistically with EMT key markers, including N-cadherin, vimentin, snail, slug, and TWIST1. Survival and Cox regression analysis showed that higher CALU predicted worse survival, and the prognostic value was independent of WHO grade and age. Conclusions: CALU was correlated with more malignant phenotypes in glioma. Moreover, CALU seemed to serve as a pro-EMT molecular target and could contribute to predict prognosis independently in glioma.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Calumenin contributes to epithelial-mesenchymal transition and predicts poor survival in glioma ; volume:12 ; number:1 ; year:2021 ; pages:67-75 ; extent:9
Translational Neuroscience ; 12, Heft 1 (2021), 67-75 (gesamt 9)
- Urheber
-
Yang, Ying
Wang, Jin
Xu, Shihai
Shi, Fei
Shan, Aijun
- DOI
-
10.1515/tnsci-2021-0004
- URN
-
urn:nbn:de:101:1-2022082914412676320442
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:33 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Yang, Ying
- Wang, Jin
- Xu, Shihai
- Shi, Fei
- Shan, Aijun
Ähnliche Objekte (12)
IKBIP is a novel EMT-related biomarker and predicts poor survival in glioma
Adaptively Fused Attention Module for the Fabric Defect Detection
Editorial
Microscopic Chromosomal Structural and Dynamical Origin of Cell Differentiation and Reprogramming
Data mining and mathematical models in cancer prognosis and prediction
Quantifying Landscape‐Flux via Single‐Cell Transcriptomics Uncovers the Underlying Mechanism of Cell Cycle
Co-firing of PZT–PMS–PZN/Ag Multilayer Actuator Prepared by Tape-Casting Method
Qualitative properties of a p-Laplacian population model with delay
Rising trends in the burden of migraine and tension-type headache among adolescents and young adults globally, 1990 to 2019
Celecoxib Alleviates Memory Deficits by Downregulation of COX-2 Expression and Upregulation of the BDNF-TrkB Signaling Pathway in a Diabetic Rat Model
The Gut Microbiome and Hepatocellular Carcinoma: Implications for Early Diagnostic Biomarkers and Novel Therapies
Polymorphisms in FADS1 and FADS2 alter plasma fatty acids and desaturase levels in type 2 diabetic patients with coronary artery disease
IKBIP is a novel EMT-related biomarker and predicts poor survival in glioma
Adaptively Fused Attention Module for the Fabric Defect Detection
Editorial
Microscopic Chromosomal Structural and Dynamical Origin of Cell Differentiation and Reprogramming
Data mining and mathematical models in cancer prognosis and prediction
Quantifying Landscape‐Flux via Single‐Cell Transcriptomics Uncovers the Underlying Mechanism of Cell Cycle
Co-firing of PZT–PMS–PZN/Ag Multilayer Actuator Prepared by Tape-Casting Method
Qualitative properties of a p-Laplacian population model with delay
Rising trends in the burden of migraine and tension-type headache among adolescents and young adults globally, 1990 to 2019
Celecoxib Alleviates Memory Deficits by Downregulation of COX-2 Expression and Upregulation of the BDNF-TrkB Signaling Pathway in a Diabetic Rat Model
The Gut Microbiome and Hepatocellular Carcinoma: Implications for Early Diagnostic Biomarkers and Novel Therapies
Polymorphisms in FADS1 and FADS2 alter plasma fatty acids and desaturase levels in type 2 diabetic patients with coronary artery disease
IKBIP is a novel EMT-related biomarker and predicts poor survival in glioma
Adaptively Fused Attention Module for the Fabric Defect Detection
Editorial
Microscopic Chromosomal Structural and Dynamical Origin of Cell Differentiation and Reprogramming
Data mining and mathematical models in cancer prognosis and prediction
Quantifying Landscape‐Flux via Single‐Cell Transcriptomics Uncovers the Underlying Mechanism of Cell Cycle
Co-firing of PZT–PMS–PZN/Ag Multilayer Actuator Prepared by Tape-Casting Method
Qualitative properties of a p-Laplacian population model with delay
Rising trends in the burden of migraine and tension-type headache among adolescents and young adults globally, 1990 to 2019
Celecoxib Alleviates Memory Deficits by Downregulation of COX-2 Expression and Upregulation of the BDNF-TrkB Signaling Pathway in a Diabetic Rat Model
The Gut Microbiome and Hepatocellular Carcinoma: Implications for Early Diagnostic Biomarkers and Novel Therapies