Bioactive Silk‐Based Nerve Guidance Conduits for Augmenting Peripheral Nerve Repair
Abstract: Repair of peripheral nerve injuries depends upon complex biology stemming from the manifold and challenging injury‐healing processes of the peripheral nervous system. While surgical treatment options are available, they tend to be characterized by poor clinical outcomes for the injured patients. This is particularly apparent in the clinical management of a nerve gap whereby nerve autograft remains the best clinical option despite numerous limitations; in addition, effective repair becomes progressively more difficult with larger gaps. Nerve conduit strategies based on tissue engineering approaches and the use of silk as scaffolding material have attracted much attention in recent years to overcome these limitations and meet the clinical demand of large gap nerve repair. This review examines the scientific advances made with silk‐based conduits for peripheral nerve repair. The focus is on enhancing bioactivity of the conduits in terms of physical guidance cues, inner wall and lumen modification, and imbuing novel conductive functionalities.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Bioactive Silk‐Based Nerve Guidance Conduits for Augmenting Peripheral Nerve Repair ; volume:7 ; number:23 ; year:2018 ; extent:20
Advanced healthcare materials ; 7, Heft 23 (2018) (gesamt 20)
- Creator
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Magaz, Adrián
Faroni, Alessandro
Gough, Julie E.
Reid, Adam J.
Li, Xu
Blaker, Jonny J.
- DOI
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10.1002/adhm.201800308
- URN
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urn:nbn:de:101:1-2022082306174272692975
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:24 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Magaz, Adrián
- Faroni, Alessandro
- Gough, Julie E.
- Reid, Adam J.
- Li, Xu
- Blaker, Jonny J.
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