Mechanisms for Reduced Fibrin Clot Formation on Liquid‐Infused Surfaces
Abstract: Biomedical devices are prone to blood clot formation (thrombosis), and liquid‐infused surfaces (LIS) are effective in reducing the thrombotic response. However, the mechanisms that underpin this performance, and in particular the role of the lubricant, are not well understood. In this work, it is investigated whether the mechanism of LIS action is related to i) inhibition of factor XII (FXII) activation and the contact pathway; ii) reduced fibrin density of clots formed on surfaces; iii) increased mobility of proteins or cells on the surface due to the interfacial flow of the lubricant. The chosen LIS is covalently tethered, nanostructured layers of perfluorocarbons, infused with thin films of medical‐grade perfluorodecalin (tethered‐liquid perfluorocarbon), prepared with chemical vapor deposition previously optimized to retain lubricant under flow. Results show that in the absence of external flow, interfacial mobility is inherently higher at the liquid–blood interface, making it a key contributor to the low thrombogenicity of LIS, as FXII activity and fibrin density are equivalent at the interface. The findings of this study advance the understanding of the anti‐thrombotic behavior of LIS‐coated biomedical devices for future coating design. More broadly, enhanced interfacial mobility may be an important, underexplored mechanism for the anti‐fouling behavior of surface coatings.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Mechanisms for Reduced Fibrin Clot Formation on Liquid‐Infused Surfaces ; day:09 ; month:09 ; year:2022 ; extent:10
Advanced healthcare materials ; (09.09.2022) (gesamt 10)
- Creator
-
Hong, Jun Ki
Ruhoff, Alexander M.
Mathur, Kavya
Neto, Chiara
Waterhouse, Anna
- DOI
-
10.1002/adhm.202201360
- URN
-
urn:nbn:de:101:1-2022091015024827737605
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:38 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Hong, Jun Ki
- Ruhoff, Alexander M.
- Mathur, Kavya
- Neto, Chiara
- Waterhouse, Anna
Other Objects (12)
Antithrombin Deficiency Is Associated with Prothrombotic Plasma Fibrin Clot Phenotype
Internal fibrinolysis of fibrin clots is driven by pore expansion
Impact of fibrinogen carbamylation on fibrin clot formation and stability
A new device for measurement of fibrin clot lysis: application to the Euglobulin Clot Lysis Time
Fabrication of liquid-infused surfaces via mussel-inspired chemistry
Fibrin clot permeability (Ks) in patients on left ventricular assist device
Phase Separation of Intrinsically Disordered Protein Polymers Mechanically Stiffens Fibrin Clots
Biofilm Bridges Forming Structural Networks on Patterned Lubricant‐Infused Surfaces
Understanding and Design of Long-Term Stable Liquid-Infused Surfaces
Fibrin Clot Structure and Platelet Aggregation in Patients with Aspirin Treatment Failure
Fibrin γ/γ' influences the secretion of fibrinolytic components and clot structure
Complement activation leads to C3 & C5 dependent prothrombotic alterations of fibrin clots
Antithrombin Deficiency Is Associated with Prothrombotic Plasma Fibrin Clot Phenotype
Internal fibrinolysis of fibrin clots is driven by pore expansion
Impact of fibrinogen carbamylation on fibrin clot formation and stability
A new device for measurement of fibrin clot lysis: application to the Euglobulin Clot Lysis Time
Fabrication of liquid-infused surfaces via mussel-inspired chemistry
Fibrin clot permeability (Ks) in patients on left ventricular assist device
Phase Separation of Intrinsically Disordered Protein Polymers Mechanically Stiffens Fibrin Clots
Biofilm Bridges Forming Structural Networks on Patterned Lubricant‐Infused Surfaces
Understanding and Design of Long-Term Stable Liquid-Infused Surfaces
Fibrin Clot Structure and Platelet Aggregation in Patients with Aspirin Treatment Failure
Fibrin γ/γ' influences the secretion of fibrinolytic components and clot structure
Complement activation leads to C3 & C5 dependent prothrombotic alterations of fibrin clots
Antithrombin Deficiency Is Associated with Prothrombotic Plasma Fibrin Clot Phenotype
Internal fibrinolysis of fibrin clots is driven by pore expansion
Impact of fibrinogen carbamylation on fibrin clot formation and stability
A new device for measurement of fibrin clot lysis: application to the Euglobulin Clot Lysis Time
Fabrication of liquid-infused surfaces via mussel-inspired chemistry
Fibrin clot permeability (Ks) in patients on left ventricular assist device
Phase Separation of Intrinsically Disordered Protein Polymers Mechanically Stiffens Fibrin Clots
Biofilm Bridges Forming Structural Networks on Patterned Lubricant‐Infused Surfaces
Understanding and Design of Long-Term Stable Liquid-Infused Surfaces
Fibrin Clot Structure and Platelet Aggregation in Patients with Aspirin Treatment Failure
Fibrin γ/γ' influences the secretion of fibrinolytic components and clot structure