Superior Tumor Cell Uptake by Mono‐ and Tri‐Nuclear Rhodamine‐Gadolinium (III) Agents

Abstract: The synthesis and characterization of a novel trinuclear rhodamine‐Gd (III) complex, along with two analogous mononuclear rhodamine‐Gd (III) complexes, are reported. All complexes displayed good selectivity in a human glioma cell line (T98G) when compared to a glial cell line (SVG p12), with low cytotoxicities. Superior tumor cell uptake for these Gd (III) complexes was observed at lower incubation concentrations compared to previously‐reported delocalized lipophilic cations such as a rhodamine‐lanthanoid (III) probe and Gd (III)‐arylphosphonium complexes, with ca. 150 % and 250 % increases in Gd uptake, respectively.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Superior Tumor Cell Uptake by Mono‐ and Tri‐Nuclear Rhodamine‐Gadolinium (III) Agents ; volume:30 ; number:55 ; year:2024 ; extent:5 ; Chemistry - a European journal ; 30, Heft 55 (2024) (gesamt 5)

Contributors, Places and Time

• Creator: Robertson, Amy G. ; Hall, Andrew J. ; Marfavi, Anita ; Rendina, Louis M.

Further information

• DOI: 10.1002/chem.202402244
• URN: urn:nbn:de:101:1-2410011456387.780402700197
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:24 AM CEST