Neutral Block Copolymer Assisted Gene Delivery using Hydrodynamic Limb Vein Injection
Abstract: Three different amphiphilic block copolymer families are synthesized to investigate new opportunities to enhance gene delivery via Hydrodynamic Limb Vein (HLV) injections. First a polyoxazoline‐based family containing mostly one poly (2‐methyl‐2‐oxazoline) (PMeOx) block and a second block POx with an ethyl (EtOx), isopropyl (iPrOx) or phenyl substituent (PhOx) is synthesized. Then an ABC poly (2‐ethyl‐2‐oxazoline)‐b‐poly (2‐n‐propyl‐2‐oxazoline)‐b‐poly (2‐methyl‐2‐oxazoline) triblock copolymer is synthesized, with a thermosensitive middle block. Finally, polyglycidol‐b‐polybutylenoxide‐b‐polyglycidol copolymers with various molar masses and amphiphilic balance are produced. The simple architecture of neutral amphiphilic triblock copolymer is not sufficient to obtain enhanced in vivo gene transfection. Double or triple amphiphilic neutral block copolymers are improving the in vivo transfection performances through HLV administration as far as a block having an lower critical solution temperature is incorporated in the vector. The molar mass of the copolymer does not seem to affect the vector performances in a significant manner.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Neutral Block Copolymer Assisted Gene Delivery using Hydrodynamic Limb Vein Injection ; day:29 ; month:03 ; year:2024 ; extent:11
Macromolecular bioscience ; (29.03.2024) (gesamt 11)
- Creator
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Guen, Yann Le
Delecourt, Gwendoline
Gall, Tony Le
Du, Haiqin
Illy, Nicolas
Huin, Cécile
Bennevault, Véronique
Midoux, Patrick
Montier, Tristan
Guégan, Philippe
- DOI
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10.1002/mabi.202300568
- URN
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urn:nbn:de:101:1-2024032913370827050897
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:55 AM CEST
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Associated
- Guen, Yann Le
- Delecourt, Gwendoline
- Gall, Tony Le
- Du, Haiqin
- Illy, Nicolas
- Huin, Cécile
- Bennevault, Véronique
- Midoux, Patrick
- Montier, Tristan
- Guégan, Philippe
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Measuring microRNA reporter activity in skeletal muscle using hydrodynamic limb vein injection of plasmid DNA combined with in vivo imaging
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Superior Ophthalmic Vein Embolism Following Forehead Augmentation with Autologous Fat Injection
Fatal haemorrhage from a lower limb varicose vein rupture: two case reports
Endoscopic injection sclerotherapy for pediatric bleeding esophageal varices complicated by gastric vein, main portal vein, splenic mesenteric junction, and splenic vein occlusion: a case report
Injection moulding of micropillar arrays: a comparison of poly(methyl methacrylate) and cyclic olefin copolymer
Hydrodynamic supercontinuum
Efficacy of intravitreal Lucentis injection on major and macular branch retinal vein occlusion
Portal and splenic vein occlusion complicating Histoacryl injection therapy in bleeding gastric varices
Detection of lower limb deep vein thrombosis: Comparison between radionuclide venography and venous ultrasonography
EUS-guided cyanoacrylate injection into the perforating vein versus direct endoscopic injection in the treatment of high-risk gastric varices
Elasto-hydrodynamic lubrication
Measuring microRNA reporter activity in skeletal muscle using hydrodynamic limb vein injection of plasmid DNA combined with in vivo imaging
Anterior Tibial Artery-Anterior Tibial Vein Deep Vein Arterialization: A Potential Option for Limb Salvage: A Case Report
Superior Ophthalmic Vein Embolism Following Forehead Augmentation with Autologous Fat Injection
Fatal haemorrhage from a lower limb varicose vein rupture: two case reports
Endoscopic injection sclerotherapy for pediatric bleeding esophageal varices complicated by gastric vein, main portal vein, splenic mesenteric junction, and splenic vein occlusion: a case report
Injection moulding of micropillar arrays: a comparison of poly(methyl methacrylate) and cyclic olefin copolymer
Hydrodynamic supercontinuum
Efficacy of intravitreal Lucentis injection on major and macular branch retinal vein occlusion
Portal and splenic vein occlusion complicating Histoacryl injection therapy in bleeding gastric varices
Detection of lower limb deep vein thrombosis: Comparison between radionuclide venography and venous ultrasonography
EUS-guided cyanoacrylate injection into the perforating vein versus direct endoscopic injection in the treatment of high-risk gastric varices