Autonomic thermoregulatory dysfunction in neurofibromatosis type 1

Abstract: Objective Neurofibromatosis type 1 (NF1) causes neural and cutaneous disorders and reduced exercise capacity. Exercise/heat exposure increasing internal temperature must be compensated by eccrine sweat function and warmed skin vasodilation. We suspected NF1 could adversely affect eccrine sweat function and/or vascular thermoregulatory responses (VTR). Methods The eccrine sweat function and VTR of 25 NF1 volunteers (14 males, 11 females; 16–57 years old) were compared with 23 non-NF1 controls matched by sex, age, height and weight (CG). Sweating was induced by 1) pilocarpine 1% iontophoresis (PILO); and 2) by passive heating (HEAT) via the lower third of the legs being immersed in 42°C water for one hour. Previously established eccrine sweat function and VTR protocols were used. Results The NF1 group showed: a) lower sweat rate than the CG group during PILO; b) a smaller diastolic pressure decrease; and c) higher tympanic temperatures than controls during HEAT (p < 0.05). Conclusion Reduced sweating and vascular thermoregulatory responses suggest autonomic dysfunction in NF1 individuals.

Object Details

• Alternative title: Disfunção autonçmica termorregulatória na neurofibromatose do tipo 1
• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Autonomic thermoregulatory dysfunction in neurofibromatosis type 1 ; volume:74 ; number:10 ; year:2016 ; pages:796-802 ; Arquivos de neuro-psiquiatria ; 74, Heft 10 (2016), 796-802

Contributors, Places and Time

• Contributor: Madeira, Luciana G. ; Passos, Renata LF ; Souza, Juliana F. de ; Rezende, Nilton A. ; Rodrigues, Luiz O. C.

Further information

• DOI: 10.1590/0004-282X20160122
• URN: urn:nbn:de:101:1-2023101912394582223966
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 11:02 AM CEST