The Role of Hepcidin and an Oral Iron Absorption Test in Identifying the Root Cause of Iron-Restricted Anemia (Enter-Iron)
Abstract: Introduction: Traditional iron parameters often fail to distinguish the cause of iron-restricted anemia in patients without an obvious underlying cause. We evaluated whether an oral iron absorption test (OIAT) and hepcidin measurement could be useful diagnostic tests in these patients. Methods: We retrospectively analyzed data extracted from medical records of all patients who underwent an OIAT and hepcidin measurement, noting subsequent clinical diagnosis. Δ Iron >15 µmol/L during the OIAT and a hepcidin level below the median (or suppressed ≤0.5 nm) were considered appropriate. Results: Thirty-nine adult patients were included in the study. Sixteen patients with adequate OIAT had suppressed hepcidin levels indicative of classical iron-deficiency anemia (IDA); 59% of patients had abnormal OIAT. In this group, most patients with low hepcidin levels had anemia associated with abnormalities in the gastrointestinal tract, whereas 83.3% patients with high hepcidin levels had iron-refractory iron-deficiency anemia (IRIDA), confirmed by genetic testing. Finally, transferrin/log ferritin ratio accurately identified patients with suppressed hepcidin: AUC 0.98 [95% CI: 0.95–1.02], p < 0.001. Conclusion: OIAT differentiates between classical IDA and other types of anemia caused by abnormalities in iron absorption or systemic iron availability. Additionally, elevated hepcidin in patients with oral iron malabsorption could indicate IRIDA.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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The Role of Hepcidin and an Oral Iron Absorption Test in Identifying the Root Cause of Iron-Restricted Anemia (Enter-Iron) ; volume:147 ; number:4 ; year:2024 ; pages:402-412 ; extent:11
Acta haematologica ; 147, Heft 4 (2024), 402-412 (gesamt 11)
- Creator
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Loveikyte, Roberta
van den Berg, Yascha
van der Meulen-de Jong, Andrea Elisabeth
Vlasveld, Lodewijk Thomas
- DOI
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10.1159/000535275
- URN
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urn:nbn:de:101:1-2408150015498.627647687117
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:50 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Loveikyte, Roberta
- van den Berg, Yascha
- van der Meulen-de Jong, Andrea Elisabeth
- Vlasveld, Lodewijk Thomas
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Safety of intravenous iron isomaltoside for iron deficiency and iron deficiency anemia in pregnancy
Direct modulation of hepatocyte hepcidin signaling by iron
Hematinic and Iron Optimization in Peri-operative Anemia and Iron Deficiency
Oral Iron Therapy-Induced Neutropenia in Patient with Iron Deficiency Anemia
Iron Deficiency Defined by Hepcidin in Critically Ill Patients
Hepcidin gene polymorphisms and iron overload in β-thalassemia major patients refractory to iron chelating therapy
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Hepcidin, an emerging and important player in brain iron homeostasis
Prevalence of anemia and iron deficiency anemia in Chinese pregnant women (IRON WOMEN): a national cross-sectional survey
Obesity modulate serum hepcidin and treatment outcome of iron deficiency anemia in children: A case control study
Erythroferrone and hepcidin levels in children with iron deficiency anemia
Hepcidin and iron parameters determine disease outcome
Safety of intravenous iron isomaltoside for iron deficiency and iron deficiency anemia in pregnancy
Direct modulation of hepatocyte hepcidin signaling by iron
Hematinic and Iron Optimization in Peri-operative Anemia and Iron Deficiency
Oral Iron Therapy-Induced Neutropenia in Patient with Iron Deficiency Anemia
Iron Deficiency Defined by Hepcidin in Critically Ill Patients
Hepcidin gene polymorphisms and iron overload in β-thalassemia major patients refractory to iron chelating therapy
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Hepcidin, an emerging and important player in brain iron homeostasis
Prevalence of anemia and iron deficiency anemia in Chinese pregnant women (IRON WOMEN): a national cross-sectional survey