Continuum‐mechanical modelling of apoptosis
Abstract: In cancer cells, the administration of drugs, such as TRAIL, can induce a mode of cell death (apoptosis). This applied reagent shifts the cell's internal inhibition and activation reactions towards the activation of caspases, triggering the cell death. In this contribution, a macroscopic model in the framework of the well‐known Theory of Porous Media is introduced to model the apoptosis reaction for lung‐cancer metastases located in brain tissue. Therein, the density‐production terms describe the apoptosis via a set of ordinary differential equations. The model is adapted to apoptosis experiments, measuring the survival rate of lung‐cancer cells in dependency of the TRAIL concentration. Thereby, the model is compared to a reduced model version using a constitutive logarithmic apoptosis function within the production terms.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Continuum‐mechanical modelling of apoptosis ; volume:19 ; number:1 ; year:2019 ; extent:2
Proceedings in applied mathematics and mechanics ; 19, Heft 1 (2019) (gesamt 2)
- Urheber
- DOI
-
10.1002/pamm.201900310
- URN
-
urn:nbn:de:101:1-2022072208074929533001
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:30 MESZ
Datenpartner
Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Schröder, Patrick
- Wagner, Arndt
- Stöhr, Daniela
- Rehm, Markus
- Ehlers, Wolfgang
Ähnliche Objekte (12)
Point defects in piezoelectric materials : continuum mechanical modelling and numerical simulation
Point defects in piezoelectric materials : continuum mechanical modelling and numerical simulation
From Beam to Higher-Order Continuum Modelling of the Mechanical Properties of Cellular Solids
Continuum-mechanical modelling across scales : homogenisation methods and their application to microstructurally-based skeletal muscle modelling
Continuum mechanical models of atomistic crystalline surface manifolds
Modelling the functional heterogeneity of skeletal muscles : enriching continuum-mechanical models on a motor-unit level
Towards material modelling within continuum-atomistics
Continuum microhaemodynamics modelling using inverse rheology
On aspects of mixed continuum atomistic material modelling
On aspects of mixed continuum atomistic material modelling
Continuum mechanical modeling aspects of self-cleaning surface mechanisms
Continuum modelling of structure formation of biosilica patterns in diatoms
Point defects in piezoelectric materials : continuum mechanical modelling and numerical simulation
Point defects in piezoelectric materials : continuum mechanical modelling and numerical simulation
From Beam to Higher-Order Continuum Modelling of the Mechanical Properties of Cellular Solids
Continuum-mechanical modelling across scales : homogenisation methods and their application to microstructurally-based skeletal muscle modelling
Continuum mechanical models of atomistic crystalline surface manifolds
Modelling the functional heterogeneity of skeletal muscles : enriching continuum-mechanical models on a motor-unit level
Towards material modelling within continuum-atomistics
Continuum microhaemodynamics modelling using inverse rheology
On aspects of mixed continuum atomistic material modelling
On aspects of mixed continuum atomistic material modelling
Continuum mechanical modeling aspects of self-cleaning surface mechanisms
Continuum modelling of structure formation of biosilica patterns in diatoms
Point defects in piezoelectric materials : continuum mechanical modelling and numerical simulation
Point defects in piezoelectric materials : continuum mechanical modelling and numerical simulation
From Beam to Higher-Order Continuum Modelling of the Mechanical Properties of Cellular Solids
Continuum-mechanical modelling across scales : homogenisation methods and their application to microstructurally-based skeletal muscle modelling
Continuum mechanical models of atomistic crystalline surface manifolds
Modelling the functional heterogeneity of skeletal muscles : enriching continuum-mechanical models on a motor-unit level
Towards material modelling within continuum-atomistics
Continuum microhaemodynamics modelling using inverse rheology
On aspects of mixed continuum atomistic material modelling
On aspects of mixed continuum atomistic material modelling
Continuum mechanical modeling aspects of self-cleaning surface mechanisms