Prevalence and characterization of pain in patients with Charcot-Marie-Tooth disease type 1A

Abstract: Background: Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common form of hereditary neuropathy. Objective: To investigate the prevalence and characteristics of pain in patients with CMT1A. Methods: Nineteen patients with a diagnosis of CMT1A were evaluated between September 2018 and October 2019, and other causes of neuropathy were ruled out. The following tools were used for the pain assessment: neurological assessment, LANSS, DN4, clinical evaluation, VAS, CMTNS2 and SF-36. Statistical analysis was performed using prevalence analysis, t test, chi-square test and Spearman's rho. Results: The prevalence of pain was 84.2% in the sample of this study, with moderate intensity and nociceptive characteristics according to the LANSS scale (75%) and clinical evaluation (50%), but differing from DN4, which found neuropathic pain in the majority of the patients (56.2%). Mixed pain was also observed in 43.7% of the patients, according to clinical criteria. There was a statistically significant correlation between pain intensity and SF-36, thus demonstrating that the lower the pain was, the lower the impairment was, in all domains. Conclusion: Pain is a prevalent and important symptom in CMT1A, with moderate intensity and nociceptive characteristics according to two tools, but neuropathic pain is also present, and there may even be a mixed pattern of pain. The correlation of the pain with SF-36 suggests that pain relief could provide improvements to the quality of life of these individuals.

Angaben zum Objekt

• Weitere Titel: Prevalência e caracterização da dor na doença de Charcot-Marie-Tooth tipo 1A
• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Prevalence and characterization of pain in patients with Charcot-Marie-Tooth disease type 1A ; volume:79 ; number:05 ; year:2021 ; pages:415-419 ; Arquivos de neuro-psiquiatria ; 79, Heft 05 (2021), 415-419

Beteiligte, Orts- und Zeitangaben

• Beteiligte Personen und Organisationen: AZEVEDO, Helen ; COSTA, Henrique ; DAVIDOVICH, Eduardo ; PUPE, Camila ; NASCIMENTO, Osvaldo José Moreira

Weitere Informationen

• DOI: 10.1590/0004-282X-ANP-2020-0132
• URN: urn:nbn:de:101:1-2023072012181856168880
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 14.08.2025, 10:58 MESZ