Thromboembolic complications in COVID-19 patients hospitalized in Italian ordinary wards: data from the multicentre observational START-COVID Reg

Background: COVID-19 infection causes acute respiratory insufficiency with severe interstitial pneumonia and extra-pulmonary complications; in particular, it may predispose to thromboembolic disease. The reported incidence of thromboembolic complications varies from 5% to 30% of cases. Aim. We conducted a multicentre, Italian, retrospective, observational study on COVID-19 patients admitted to ordinary wards, to describe clinical characteristic of patients at admission, bleeding and thrombotic events occurring during hospital stay. Results: 1135 patients hospitalized were included in the START-COVID-19 Register, 1091 patients hospitalized in ordinary wards were included in the study, 653 males (59.9%), median age 71 years (IQR 59-82 years). During the observation, 2 (0.2%) patients had acute coronary syndrome episodes, 1 patient (0.1%) had an ischemic stroke; no other arterial thrombotic events were recorded. Fifty-nine patients had symptomatic VTE (5.4%) events, including 18 (30.5%) deep vein thrombosis (DVT), 39 (66.1%) pulmonary embolism (PE), and 2 (3.4%) DVT + PE. Among patients with DVT, 8 (44.4%) were isolated distal DVT, and 2 cases were jugular thrombosis. Among patients with PE, 7 (17.9%) events were limited to sub-segmental arteries. No fatal PE were recorded. Major bleedings occurred in 9 (1.2%) patients, and clinically relevant non-major bleeding in 9 (1.2%) patients. All bleedings occurred among patients receiving thromboprophylaxis, more frequently when treated with sub-therapeutic or therapeutic dosages. Conclusion: Our findings confirm that patients admitted to ordinary wards for COVID-19 infection are at high risk for thromboembolic events. VTE recorded among these patients are mainly isolated PE, suggesting a peculiar characteristic of VTE in these patients.

Object Details

• Alternative title: Thromboembolic complications in COVID-19 patients
• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Thromboembolic complications in COVID-19 patients hospitalized in Italian ordinary wards: data from the multicentre observational START-COVID Reg ; day:19 ; month:06 ; year:2022 ; TH open ; (19.06.2022)

Contributors, Places and Time

• Contributor: Poli, Daniela ; Antonucci, Emilia ; Ageno, Walter ; Prandoni, Paolo ; Barillari, Giovanni ; Bitti, Giuseppina ; Imbalzano, Egidio ; Bucherini, Eugenio ; CHISTOLINI, Antonio ; Fregoni, Vittorio ; Galliazzo, Silvia ; Gandolfo, Alberto ; Grifoni, Elisa ; Mastroianni, Franco ; Panarello, Serena ; Pesavento, Raffaele ; Pedrini, Simona ; Sala, Girolamo ; Pignatelli, Pasquale ; Preti, Paola Stefania ; Simonetti, Federico ; Sivera, Piera ; Visoná, Adriana ; Villalta, Sabina ; Marcucci, Rossella ; Palareti, Gualtiero

Further information

• DOI: 10.1055/a-1878-6806
• URN: urn:nbn:de:101:1-2022080408034300736256
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 17.07.0015, 12:30 AM CET