CD169+ Macrophages Mediate the Immune Response of Allergic Rhinitis Through the Keap1/Nrf2/HO‐1 Axis
Abstract: CD169+ macrophages are a newly defined macrophage subpopulation that can recognize and bind with other cells through related ligands, playing an essential role in antigen presentation and immune tolerance. However, its role in Allergic Rhinitis (AR) is still unclear. To investigate the characteristics of CD169+ macrophages in AR, this work first detects their expression patterns in the nasal mucosa of clinical patients. These results show a significant increase in CD169+ macrophages in the nasal mucosa of patients with AR. Subsequently, this work establishes an animal AR model using CD169 transgenic mice and compared the advantages of the two models. Moreover, this work also demonstrates the effects of CD169 knockout on eosinophils, Th cells, Treg cells, and the migration of dendritic cells (DCs). In addition, this metabolomic data shows that CD169+ macrophages can upregulate alanine production and increase reactive oxygen species (ROS) levels. This process may be mediated through the Keap1/Nrf2/HO‐1 signaling pathway. In addition, this work also finds that SLC38A2 plays an essential role in the process of CD169+ macrophages promoting alanine uptake by DCs. This study confirms that CD169+ macrophages can upregulate their internal alanine production and increase ROS levels through the Keap1/Nrf2/HO‐1 axis, playing an irreplaceable role in AR.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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CD169+ Macrophages Mediate the Immune Response of Allergic Rhinitis Through the Keap1/Nrf2/HO‐1 Axis ; day:22 ; month:10 ; year:2024 ; extent:21
Advanced science ; (22.10.2024) (gesamt 21)
- Creator
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Qi, Wenwen
Liu, Chengcheng
Shi, Lei
Li, Hui
Hou, Xiaozhi
Du, Hongjie
Chen, Luqiu
Gao, Xiaochen
Cao, Xue
Guo, Na
Dong, Yuhan
Li, Chengzhilin
Yuan, Fanyu
Teng, Zhenxiao
Hu, Houyang
Zhu, Fangyuan
Zhou, Xuanchen
Guo, Lulu
Zhao, Miaoqing
Xia, Ming
- DOI
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10.1002/advs.202309331
- URN
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urn:nbn:de:101:1-2410221442226.388058271445
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:22 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Qi, Wenwen
- Liu, Chengcheng
- Shi, Lei
- Li, Hui
- Hou, Xiaozhi
- Du, Hongjie
- Chen, Luqiu
- Gao, Xiaochen
- Cao, Xue
- Guo, Na
- Dong, Yuhan
- Li, Chengzhilin
- Yuan, Fanyu
- Teng, Zhenxiao
- Hu, Houyang
- Zhu, Fangyuan
- Zhou, Xuanchen
- Guo, Lulu
- Zhao, Miaoqing
- Xia, Ming
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