Establishment of a Magnetically Controlled Scalable Nerve Injury Model
Abstract: Animal models of peripheral nerve injury (PNI) serve as the fundamental basis for the investigations of nerve injury, regeneration, and neuropathic pain. The injury properties of such models, including the intensity and duration, significantly influence the subsequent pathological changes, pain development, and therapeutic efficacy. However, precise control over the intensity and duration of nerve injury remains challenging within existing animal models, thereby impeding accurate and comparative assessments of relevant cases. Here, a new model that provides quantitative and off‐body controllable injury properties via a magnetically controlled clamp, is presented. The clamp can be implanted onto the rat sciatic nerve and exert varying degrees of compression under the control of an external magnetic field. It is demonstrated that this model can accurately simulate various degrees of pathology of human patients by adjusting the magnetic control and reveal specific pathological changes resulting from intensity heterogeneity that are challenging to detect previously. The controllability and quantifiability of this model may significantly reduce the uncertainty of central response and inter‐experimenter variability, facilitating precise investigations into nerve injury, regeneration, and pain mechanisms.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Establishment of a Magnetically Controlled Scalable Nerve Injury Model ; day:17 ; month:09 ; year:2024 ; extent:12
Advanced science ; (17.09.2024) (gesamt 12)
- Urheber
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Yang, Tuo
Liu, Xilin
Cao, Rangjuan
Zhou, Xiongyao
Li, Weizhen
Wu, Wenzheng
Yu, Wei
Zhang, Xianyu
Guo, Zhengxiao
Cui, Shusen
- DOI
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10.1002/advs.202405265
- URN
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urn:nbn:de:101:1-2409171427424.545458669395
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:27 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Yang, Tuo
- Liu, Xilin
- Cao, Rangjuan
- Zhou, Xiongyao
- Li, Weizhen
- Wu, Wenzheng
- Yu, Wei
- Zhang, Xianyu
- Guo, Zhengxiao
- Cui, Shusen
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