miR‐132 loss de‐represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain

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Abstract: microRNA‐132 (miR‐132) is involved in prosurvival, anti‐inflammatory and memory‐promoting functions in the nervous system and has been found consistently downregulated in Alzheimer's disease (AD). Whether and how miR‐132 deficiency impacts AD pathology remains, however, unaddressed. We show here that miR‐132 loss exacerbates both amyloid and TAU pathology via inositol 1,4,5‐trisphosphate 3‐kinase B (ITPKB) upregulation in an AD mouse model. This leads to increased ERK1/2 and BACE1 activity and elevated TAU phosphorylation. We confirm downregulation of miR‐132 and upregulation of ITPKB in three distinct human AD patient cohorts, indicating the pathological relevance of this pathway in AD.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: miR‐132 loss de‐represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain ; volume:8 ; number:9 ; year:2016 ; pages:1005-1018 ; extent:14
EMBO molecular medicine / European Molecular Biology Organization ; 8, Heft 9 (2016), 1005-1018 (gesamt 14)

Creator: Salta, Evgenia
Sierksma, Annerieke
Vanden Eynden, Elke
De Strooper, Bart

DOI: 10.15252/emmm.201606520

URN: urn:nbn:de:101:1-2022111004325308049763

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:30 AM CEST

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Salta, Evgenia
Sierksma, Annerieke
Vanden Eynden, Elke
De Strooper, Bart

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miR‐132 loss de‐represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain

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Other Objects (12)

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