CircHIPK2 Contributes Cell Growth in Intestinal Epithelial of Colitis and Colorectal Cancer through Promoting TAZ Translation
Abstract: Colorectal cancer (CRC) and inflammatory bowel disease (IBD) are escalating global health concerns. Despite their distinct clinical presentations, both disorders share intricate genetic and molecular interactions. The Hippo signaling pathway plays a crucial role in regulating cell processes and is implicated in the pathogenesis of IBD and CRC. Circular RNAs (circRNAs) have gained attention for their roles in various diseases, including IBD and CRC. However, a comprehensive understanding of specific circRNAs involved in both IBD and CRC, and their functional roles is lacking. Here, it is found that circHIPK2 (hsa_circRNA_104507) is a bona fide circRNA consistently upregulated in both IBD and CRC suggesting its potential as a biomarker. Furthermore, silencing of circHIPK2 suppressed the growth of CRC cells in vitro and in vivo. Interestingly, decreased circHipk2 potentiated dextran sulfate sodium (DSS)‐induced colitis but alleviated colitis‐associated tumorigenesis. Most significantly, mechanistic investigations further unveil that circHIPK2, mediated by FUS, interacting with EIF4A3 to promote the translation of TAZ, ultimately increasing the transcription of downstream target genes CCN1 and CCN2. Taken together, circHIPK2 emerges as a key player in the shared mechanisms of IBD and CRC, modulating the Hippo signaling pathway. CircHIPK2‐EIF4A3 axis contributes to cell growth in intestinal epithelial of colitis and CRC by enhancing TAZ translation.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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CircHIPK2 Contributes Cell Growth in Intestinal Epithelial of Colitis and Colorectal Cancer through Promoting TAZ Translation ; day:09 ; month:07 ; year:2024 ; extent:16
Advanced science ; (09.07.2024) (gesamt 16)
- Urheber
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Zeng, Xixi
Tang, Jielin
Zhang, Qian
Wang, Chenxing
Qi, Ji
Wei, Yusi
Xu, Jiali
Yang, Kaiyuan
Zhou, Zuolin
Wu, Hao
Luo, Jiarong
Jiang, Yi
Song, Zengqiang
Wu, Jinyu
Wu, Jianmin
- DOI
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10.1002/advs.202401588
- URN
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urn:nbn:de:101:1-2407101423304.299714108714
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 10:44 MESZ
Datenpartner
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Beteiligte
- Zeng, Xixi
- Tang, Jielin
- Zhang, Qian
- Wang, Chenxing
- Qi, Ji
- Wei, Yusi
- Xu, Jiali
- Yang, Kaiyuan
- Zhou, Zuolin
- Wu, Hao
- Luo, Jiarong
- Jiang, Yi
- Song, Zengqiang
- Wu, Jinyu
- Wu, Jianmin
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