Selective Interaction of Chiral Carbon Dots with Nucleic Acids: A Promising Nanosensing Platform
Abstract: Carbon dots (CDs) represent an emerging class of nanomaterials that combine outstanding photoluminescent properties with low toxicity and excellent biocompatibility. These unique features have garnered significant interest for potential applications in sensing as well as nanovectors for bioactive compounds. Within this context, the possibility of synthesizing chiral carbon dots (CCDs) has paved the way for a plethora of bioapplications in their interaction with chiral biomolecules. In this study we report the synthesis and characterization of CCDs with opposite chiralities and their selective interaction with nucleic acids. A systematic study on their interaction with different oligonucleotides (ODNs) using UV‐vis, photoluminescence, and circular dichroism analyses highlighted how the chiral surface of the CCDs induces distinct spectroscopic responses in CCDs‐ODN conjugates. These findings establish the foundation for innovative applications of CCDs as nanosensors and nanocarriers for nucleic acids. Additionally, the antioxidant properties of CCDs were investigated, highlighting their dual potential as both sensing and preservative nanomaterials for genetic material. Our results suggest significant implications for the development of chiral‐specific diagnostic tools, drug delivery systems, and therapeutic agents. Furthermore, these properties open new avenues for the use of CCDs in antibiotic residue detection, fluorescence imaging, and photodynamic therapy.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Selective Interaction of Chiral Carbon Dots with Nucleic Acids: A Promising Nanosensing Platform ; day:29 ; month:10 ; year:2024 ; extent:9
Chemistry - a European journal ; (29.10.2024) (gesamt 9)
- Creator
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Maria Vitagliano, Chiara
Camilli, Alessandro
Georgian Moldoveanu, Vyali
Di Sabato, Antonio
Feroci, Marta
Sturabotti, Elisa
Scognamiglio, Viviana
Leonelli, Francesca
Masi, Annalisa
Vetica, Fabrizio
- DOI
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10.1002/chem.202402787
- URN
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urn:nbn:de:101:1-2410291359060.051152349146
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:27 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Maria Vitagliano, Chiara
- Camilli, Alessandro
- Georgian Moldoveanu, Vyali
- Di Sabato, Antonio
- Feroci, Marta
- Sturabotti, Elisa
- Scognamiglio, Viviana
- Leonelli, Francesca
- Masi, Annalisa
- Vetica, Fabrizio
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