Defects of corneocyte structural proteins and epidermal barrier in atopic dermatitis

Abstract: The main function of the epidermis is to establish a vital multifunctional barrier between the body and its external environment. A defective epidermal barrier is one of the key features of atopic dermatitis (AD), a chronic and relapsing inflammatory skin disorder that affects up to 20% of children and 2–3% of adults and often precedes the development of allergic rhinitis and asthma. This review summarizes recent discoveries on the origin of the skin barrier alterations in AD at the structural protein level, including hereditary and acquired components. The consequences of the epidermal barrier alteration on our current understanding of the pathogenesis of AD, and its possible implications on the treatment of patients, are discussed here.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Defects of corneocyte structural proteins and epidermal barrier in atopic dermatitis ; volume:396 ; number:11 ; year:2015 ; pages:1163-1179 ; extent:17 ; Biological chemistry ; 396, Heft 11 (2015), 1163-1179 (gesamt 17)

Contributors, Places and Time

• Creator: Le Lamer, Marina ; Pellerin, Laurence ; Reynier, Marie ; Cau, Laura ; Pendaries, Valérie ; Leprince, Corinne ; Méchin, Marie-Claire ; Serre, Guy ; Paul, Carle ; Simon, Michel

Further information

• DOI: 10.1515/hsz-2015-0141
• URN: urn:nbn:de:101:1-2408051743238.580840466645
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 11:02 AM CEST