Activation of C-fiber nociceptors by low-power diode laser

Abstract: Objective The evaluation of selective activation of C-fibers to record evoked potentials using the association of low-power diode laser (810 nm), tiny-area stimulation and skin-blackening. Method Laser-evoked potentials (LEPs) were obtained from 20 healthy young subjects. An aluminum plate with one thin hole was attached to the laser probe to provide tiny-area stimulation of the hand dorsum and the stimulated area was covered with black ink. Results The mean intensity used for eliciting the ultra-late laser-evoked potential (ULEP) was 70 ± 32 mW. All subjects showed a clear biphasic potential that comprised a negative peak (806 ± 61 ms) and a positive deflection (1033 ± 60 ms), corresponding to the ULEP related to C-fiber activation. Conclusion C-fiber-evoked responses can be obtained using a very low-power diode laser when stimulation is applied to tiny areas of darkened skin. This strategy offers a non-invasive and easy methodology that minimizes damage to the tissue.

Object Details

• Alternative title: Ativação por laser de diodo de baixa potência de nociceptores relacionados a fibras C
• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Activation of C-fiber nociceptors by low-power diode laser ; volume:74 ; number:03 ; year:2016 ; pages:223-227 ; Arquivos de neuro-psiquiatria ; 74, Heft 03 (2016), 223-227

Contributors, Places and Time

• Contributor: Azevedo, Eduardo ; Silva, Andressa ; Martins, Raquel ; Andersen, Monica L. ; Tufik, Sergio ; Manzano, Gilberto M.

Further information

• DOI: 10.1590/0004-282X20160018
• URN: urn:nbn:de:101:1-2023101912185184646263
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:47 AM CEST