Effect of late-onset hemorrhagic cystitis on PFS after haplo-PBSCT
Introduction: This study is to investigate the effect of late-onset hemorrhagic cystitis (LOHC) on progression-free survival (PFS) of patients after haploidentical peripheral blood hematopoietic stem cell transplantation (haplo-PBSCT). Methods: This retrospective study enrolled 74 patients with hematological malignancies treated with a myeloablative conditioning regimen and haplo-PBSCT. The effect of LOHC on PFS was studied in terms of HC occurrence, grade, disease type, duration, onset time, gender, and age. Results: There were 28 patients with LOHC, and no case was with early-onset HC. The cumulative incidence of LOHC was 37.8% (95% CI: 26.9–48.7%). The 2-year expected PFS of 74 patients and 34 AML patients was not significantly different between LOHC patients and patients without HC (P > 0.05). Among 27 ALL patients, the 2-year expected PFS of LOHC patients was 75%, significantly higher than patients without HC (54.2%) (P < 0.05). The 2-year expected PFSs of patients with mild LOHC and severe LOHC were 69.8 and 77.8%, respectively (P > 0.05). Similarly, the onset time, duration, age, and gender of LOHC patients did not show significant effects on PFS (P > 0.05). Conclusions: After haplo-PBSCT, LOHC has a significant effect on the PFS of ALL patients. The HC grade, duration, onset time, gender, and age have no significant effect on PFS.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Effect of late-onset hemorrhagic cystitis on PFS after haplo-PBSCT ; volume:16 ; number:1 ; year:2021 ; pages:1493-1502 ; extent:10
Open medicine ; 16, Heft 1 (2021), 1493-1502 (gesamt 10)
- Creator
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Yuan, Hailong
Chen, Gang
Qu, Jianhua
Yang, Ruixue
Muhashi, Maria
Aizezi, Gulibadanmu
Jiang, Ming
- DOI
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10.1515/med-2021-0368
- URN
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urn:nbn:de:101:1-2022092014053132818407
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:36 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Yuan, Hailong
- Chen, Gang
- Qu, Jianhua
- Yang, Ruixue
- Muhashi, Maria
- Aizezi, Gulibadanmu
- Jiang, Ming
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