Evaluation of the role of some non-enzymatic antioxidants among Iraqi patients with non-alcoholic fatty liver disease
Abstract: Non-alcoholic fatty liver disease (NAFLD), characterized by hepatic fat accumulation in individuals consuming little or no alcohol, has become highly prevalent globally. Oxidative stress plays a central role in instigating inflammation and cell death pathways driving NAFLD progression. This case–control study aimed to elucidate the association between circulating levels of the pivotal non-enzymatic antioxidants – coenzyme Q10 and vitamins E and C – and liver injury parameters among 60 Iraqi NAFLD patients versus 30 healthy controls. NAFLD diagnosis entailed over 5% hepatic steatosis on ultrasound excluding other etiologies. Patients spanned three age groups: 20–29, 30–39, and 40–49. Substantially diminished antioxidant levels concurrent with elevated alkaline phosphatase enzyme were unveiled in NAFLD patients relative to controls (all p < 0.001). Age-based analysis reinforced widespread antioxidant depletion and liver enzyme augmentation across NAFLD patients. Significant correlations also emerged between antioxidants and liver parameters. Our novel observations confirm an antioxidant inadequacy likely perpetuating pathogenic oxidative reactions in NAFLD. Restoring such deficits through lifestyle or therapeutic interventions may confer preventative and disease-modifying value.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Evaluation of the role of some non-enzymatic antioxidants among Iraqi patients with non-alcoholic fatty liver disease ; volume:19 ; number:1 ; year:2024 ; extent:7
Open life sciences ; 19, Heft 1 (2024) (gesamt 7)
- Creator
-
Hussein, Ammar L.
Nema, Dunia T.
Nasir, Gulboy A.
- DOI
-
10.1515/biol-2022-0881
- URN
-
urn:nbn:de:101:1-2406271544486.340303318359
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
14.03.2025, 5:59 PM CET
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Hussein, Ammar L.
- Nema, Dunia T.
- Nasir, Gulboy A.
Other Objects (12)
Peripheral non-enzymatic antioxidants in patients with schizophrenia: a case-control study
Evaluation of serum amino acids and non-enzymatic antioxidants in drug-naïve first-episode major depressive disorder
Effects of vitamin E supplementation on renal non-enzymatic antioxidants in young rats submitted to exhaustive exercise stress
Relationship between hyperglycemia, antioxidant capacity and some enzymatic and non-enzymatic antioxidants in African patients with type 2 diabetes
Template‐Directed Copying of RNA by Non‐enzymatic Ligation †
Non-enzymatic post-translational modifications of bovine milk proteins
Non-enzymatic reactions in biogenesis of fungal natural products
Non‐Enzymatic RNA Backbone Proofreading through Energy‐Dissipative Recycling
Non‐Enzymatic RNA Backbone Proofreading through Energy‐Dissipative Recycling
Template‐Directed Copying of RNA by Non‐enzymatic Ligation †
Non‐Enzymatic Assembly of a Minimized RNA Polymerase Ribozyme
Chemical carcinogens in non-enzymatic cytosine deamination: 3-isocyanatoacrylonitrile
Peripheral non-enzymatic antioxidants in patients with schizophrenia: a case-control study
Evaluation of serum amino acids and non-enzymatic antioxidants in drug-naïve first-episode major depressive disorder
Effects of vitamin E supplementation on renal non-enzymatic antioxidants in young rats submitted to exhaustive exercise stress
Relationship between hyperglycemia, antioxidant capacity and some enzymatic and non-enzymatic antioxidants in African patients with type 2 diabetes
Template‐Directed Copying of RNA by Non‐enzymatic Ligation †
Non-enzymatic post-translational modifications of bovine milk proteins
Non-enzymatic reactions in biogenesis of fungal natural products
Non‐Enzymatic RNA Backbone Proofreading through Energy‐Dissipative Recycling
Non‐Enzymatic RNA Backbone Proofreading through Energy‐Dissipative Recycling
Template‐Directed Copying of RNA by Non‐enzymatic Ligation †
Non‐Enzymatic Assembly of a Minimized RNA Polymerase Ribozyme
Chemical carcinogens in non-enzymatic cytosine deamination: 3-isocyanatoacrylonitrile
Peripheral non-enzymatic antioxidants in patients with schizophrenia: a case-control study
Evaluation of serum amino acids and non-enzymatic antioxidants in drug-naïve first-episode major depressive disorder
Effects of vitamin E supplementation on renal non-enzymatic antioxidants in young rats submitted to exhaustive exercise stress
Relationship between hyperglycemia, antioxidant capacity and some enzymatic and non-enzymatic antioxidants in African patients with type 2 diabetes
Template‐Directed Copying of RNA by Non‐enzymatic Ligation †
Non-enzymatic post-translational modifications of bovine milk proteins
Non-enzymatic reactions in biogenesis of fungal natural products
Non‐Enzymatic RNA Backbone Proofreading through Energy‐Dissipative Recycling
Non‐Enzymatic RNA Backbone Proofreading through Energy‐Dissipative Recycling
Template‐Directed Copying of RNA by Non‐enzymatic Ligation †
Non‐Enzymatic Assembly of a Minimized RNA Polymerase Ribozyme