The role of glial cells and synapse loss in mouse models of Alzheimer's disease

zu Verbundenen Objekten

Abstract: Synapse loss has detrimental effects on cellular communication, leading to network disruptions within the central nervous system (CNS) such as in Alzheimer’s disease (AD). AD is characterized by a progressive decline of memory function, cognition, neuronal and synapse loss. The two main neuropathological hallmarks are amyloid-β (Aβ) plaques and neurofibrillary tangles. In the brain of AD patients and in mouse models of AD several morphological and functional changes, such as microgliosis and astrogliosis around Aβ plaques, as well as dendritic and synaptic alterations, are associated with these lesions. In this review article, we will summarize the current literature on synapse loss in mouse models of AD and discuss current and prospective treatments for AD

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Schlagwort
Alzheimerkrankheit
Amyloid
Gliazelle
Astrozyt

Ereignis
Veröffentlichung
(wo)
Freiburg
(wer)
Universität
(wann)
2019
Urheber

DOI
10.3389/fncel.2018.00473
URN
urn:nbn:de:bsz:25-freidok-171680
Rechteinformation
Kein Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
14.08.2025, 10:45 MESZ

Datenpartner

Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Original beim Datenpartner anzeigen

Beteiligte

Entstanden

  • 2019

Ähnliche Objekte (12)

Synapse loss and progress of Alzheimer’s disease -A network model

Synapse loss and progress of Alzheimer’s disease -A network model

The clinical promise of biomarkers of synapse damage or loss in Alzheimer’s disease

The clinical promise of biomarkers of synapse damage or loss in Alzheimer’s disease

Glial cell reactivity in mouse models reflecting different aspects of Alzheimer's disease

Hochschulschrift

Glial cell reactivity in mouse models reflecting different aspects of Alzheimer's disease

Glial cell reactivity in mouse models reflecting different aspects of Alzheimer's disease

Hochschulschrift

Glial cell reactivity in mouse models reflecting different aspects of Alzheimer's disease

Neuronal transcriptome, tau and synapse loss in Alzheimer’s knock-in mice require prion protein

Neuronal transcriptome, tau and synapse loss in Alzheimer’s knock-in mice require prion protein

Jacob-induced transcriptional inactivation of CREB promotes Ab-induced synapse loss in Alzheimer’s disease

Jacob-induced transcriptional inactivation of CREB promotes Ab-induced synapse loss in Alzheimer’s disease

Downregulating ANP32A rescues synapse and memory loss via chromatin remodeling in Alzheimer model

Downregulating ANP32A rescues synapse and memory loss via chromatin remodeling in Alzheimer model

APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids

APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids

Jacob‐induced transcriptional inactivation of CREB promotes Aβ‐induced synapse loss in Alzheimer's disease

Jacob‐induced transcriptional inactivation of CREB promotes Aβ‐induced synapse loss in Alzheimer's disease

“Glial inhibition” of memory in Alzheimer’s disease

“Glial inhibition” of memory in Alzheimer’s disease

Increased expression of mesencephalic astrocyte-derived neurotrophic factor (MANF) contributes to synapse loss in Alzheimer’s disease

Increased expression of mesencephalic astrocyte-derived neurotrophic factor (MANF) contributes to synapse loss in Alzheimer’s disease

Neurotransmitter transporters expressed in glial cells as regulators of synapse function

Neurotransmitter transporters expressed in glial cells as regulators of synapse function

Verbundene Objekte