Loading of Amino Acids onto RNA in a Putative RNA‐Peptide World
Abstract: RNA is a molecule that can both store genetic information and perform catalytic reactions. This observed dualism places RNA into the limelight of concepts about the origin of life. The RNA world concept argues that life started from self‐replicating RNA molecules, which evolved toward increasingly complex structures. Recently, we demonstrated that RNA, with the help of conserved non‐canonical nucleosides, which are also putative relics of an early RNA world, had the ability to grow peptides covalently connected to RNA nucleobases, creating RNA‐peptide chimeras. It is conceivable that such molecules, which combined the information‐coding properties of RNA with the catalytic potential of amino acid side chains, were once the structures from which life emerged. Herein, we report prebiotic chemistry that enabled the loading of both nucleosides and RNAs with amino acids as the first step toward RNA‐based peptide synthesis in a putative RNA‐peptide world.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Loading of Amino Acids onto RNA in a Putative RNA‐Peptide World ; day:17 ; month:04 ; year:2023 ; extent:9
Angewandte Chemie / International edition. International edition ; (17.04.2023) (gesamt 9)
- Urheber
-
Singer, Johannes N.
Müller, Felix M.
Węgrzyn, Ewa
Hölzl, Christina
Hurmiz, Hans
Liu, Chuyi
Escobar, Luis
Carell, Thomas
- DOI
-
10.1002/anie.202302360
- URN
-
urn:nbn:de:101:1-2023041815015346425483
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
14.08.2025, 10:54 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Singer, Johannes N.
- Müller, Felix M.
- Węgrzyn, Ewa
- Hölzl, Christina
- Hurmiz, Hans
- Liu, Chuyi
- Escobar, Luis
- Carell, Thomas
Ähnliche Objekte (12)
Roles of the putative RNA helicase HELZ in mRNA regulation
Prediction of RNA-binding amino acids from protein and RNA sequences
CheRRI - accurate classification of the biological relevance of putative RNA–RNA interaction sites
A rapid method to screen putative mRNA targets of any known microRNA
A putative role for amino acid permeases in sink-source communication of barley tissues uncovered by RNA-seq
Amino Acid Modified RNA Bases as Building Blocks of an Early Earth RNA‐Peptide World
Conserved roles of chromatin remodellers in cohesin loading onto chromatin
TRIM25 dictates selective miRNA loading into extracellular vesicles during inflammation
Alternative genetic code for amino acids and transfer RNA revisited
Analysis of peptide loading onto MHC class II molecules in vivo
MechRNA: prediction of lncRNA mechanisms from RNA–RNA and RNA–protein interactions
Synergistic siRNA Loading of Extracellular Vesicles Enables Functional Delivery into Cells
Roles of the putative RNA helicase HELZ in mRNA regulation
Prediction of RNA-binding amino acids from protein and RNA sequences
CheRRI - accurate classification of the biological relevance of putative RNA–RNA interaction sites
A rapid method to screen putative mRNA targets of any known microRNA
A putative role for amino acid permeases in sink-source communication of barley tissues uncovered by RNA-seq
Amino Acid Modified RNA Bases as Building Blocks of an Early Earth RNA‐Peptide World
Conserved roles of chromatin remodellers in cohesin loading onto chromatin
TRIM25 dictates selective miRNA loading into extracellular vesicles during inflammation
Alternative genetic code for amino acids and transfer RNA revisited
Analysis of peptide loading onto MHC class II molecules in vivo
MechRNA: prediction of lncRNA mechanisms from RNA–RNA and RNA–protein interactions
Synergistic siRNA Loading of Extracellular Vesicles Enables Functional Delivery into Cells
Roles of the putative RNA helicase HELZ in mRNA regulation
Prediction of RNA-binding amino acids from protein and RNA sequences
CheRRI - accurate classification of the biological relevance of putative RNA–RNA interaction sites
A rapid method to screen putative mRNA targets of any known microRNA
A putative role for amino acid permeases in sink-source communication of barley tissues uncovered by RNA-seq
Amino Acid Modified RNA Bases as Building Blocks of an Early Earth RNA‐Peptide World
Conserved roles of chromatin remodellers in cohesin loading onto chromatin
TRIM25 dictates selective miRNA loading into extracellular vesicles during inflammation
Alternative genetic code for amino acids and transfer RNA revisited
Analysis of peptide loading onto MHC class II molecules in vivo
MechRNA: prediction of lncRNA mechanisms from RNA–RNA and RNA–protein interactions