Olive‐Derived Antioxidant Dietary Fiber Modulates Gut Microbiota Composition and Attenuates Atopic Dermatitis Like Inflammation in Mice

Scope: Epidemiological data suggest that altered gut microbiota contributes to the development of atopic dermatitis (AD). The effect of an olive‐derived antioxidant dietary fiber (OADF) in relieving AD symptoms in a murine model of 2,4‐dinitrofluorobenzene (DNFB)‐induced AD is examined and the effect of OADF in modulating host gut microbiota is explored. Methods and results: Mice are fed with either standard diet or standard diet + OADF for 3 weeks prior to induction of AD and maintained on the same diet throughout the DNFB application period. Dietary OADF causes significant improvement of AD‐like symptoms with reduced serum levels of immunoglobulin (Ig) E, interleukin (IL)‐1β, IL‐6, C‐X‐C motif ligand (CXCL) 1, and increased serum levels of IL‐10. OADF supplementation restore gut microbiota composition that are altered in AD mice. Specifically, OADF increases the proportion of intestinal bacteria (Ruminococcaceae UCG014, GCA900066575, UBA1819) associated with enhanced butyrate production, along with inhibiting Clostridiales vadin BB60 which are more prevalent in AD mice. Conclusion: OADF modulates gut microbiota composition, improves cytokine profile and butyrate production influencing AD‐associated immune response. Results highlight the importance of the gut‐skin axis for the AD dietary therapeutic agents.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Olive‐Derived Antioxidant Dietary Fiber Modulates Gut Microbiota Composition and Attenuates Atopic Dermatitis Like Inflammation in Mice ; day:28 ; month:03 ; year:2023 ; extent:13 ; Molecular nutrition & food research ; (28.03.2023) (gesamt 13)

Beteiligte, Orts- und Zeitangaben

• Urheber: Lee, Ying Hui ; Kalailingam, Pazhanichamy ; Delcour, Jan A. ; Fogliano, Vincenzo ; Thanabalu, Thirumaran

Weitere Informationen

• DOI: 10.1002/mnfr.202200127
• URN: urn:nbn:de:101:1-2023032915124149261709
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 14.08.2025, 11:00 MESZ