The altered expression of cytoskeletal and synaptic remodeling proteins during epilepsy

Abstract: The cytoskeleton plays an important role in epilepsy; however, the mechanism is unknown. Therefore, this study aimed to reveal the mechanism of cytoskeletal proteins in epilepsy by investigating the expression of cytoskeletal proteins and synaptophysin (SYP) in mice at 0, 3, 6, and 24 h, 3 days, and 7 days in a kainic acid (KA)-induced epileptic model. Our results demonstrated that the expression of F-actin decreased significantly between 3 and 6 h, 6 and 24 h, and 24 h and 3 days (P < 0.05). Meanwhile, the expression of the neurofilament light chain, neurofilament medium chain, and neurofilament heavy chain subunits was significantly decreased (P < 0.001) at 3 h after the KA injection compared to the KA 0 h group, followed by an elevation at 6 h and a further decrease at 24 h compared to at 6 h. SYP expression was significantly decreased between 0 and 3 h as well as between 3 and 6 h (P < 0.05). At 24 h, the level was increased compared to at 6 h and continued to increase at 3 days after the KA injection. Thus, we propose that cytoskeletal proteins may be involved in the pathogenesis of epilepsy.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: The altered expression of cytoskeletal and synaptic remodeling proteins during epilepsy ; volume:18 ; number:1 ; year:2023 ; extent:8 ; Open life sciences ; 18, Heft 1 (2023) (gesamt 8)

Beteiligte, Orts- und Zeitangaben

• Urheber: Xin, Yanbao ; Lin, Guojiao ; Hua, Tianbao ; Liang, Jianmin ; Sun, Tianmeng ; Wu, Xuemei

Weitere Informationen

• DOI: 10.1515/biol-2022-0595
• URN: urn:nbn:de:101:1-2023041114021322862108
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 14.08.2025, 11:00 MESZ