Top ten discoveries of the year: Neurovascular disease

Abstract: The aim of this review is to highlight novel findings in 2019 in the area of neurovascular disease. Experimental studies have provided insight into disease development, molecular determinants of pathology, and putative novel therapeutic targets. Studies in genetic experimental models as well as monogenic forms of human cere-brovascular diseases identified pathogenic molecules that may also be relevant to sporadic cases. There have been advances in understanding the development of cerebral cavernous angiomas and arteriovenous malfor-mations, and putative curative treatments have been suggested from experimental models. Key pathogenic pathways involved in vessel calcification and stiffness have also been identified. At the cellular level, studies showed that proper function of endothelial and mural cells, particularly pericytes, is crucial to ensure full endo-thelial differentiation and blood-brain barrier integrity. Moreover, recent discoveries support the existence of a homeostati.... https://www.uni-muenster.de/Ejournals/index.php/fnp/article/view/2615

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Top ten discoveries of the year: Neurovascular disease ; volume:1 ; day:30 ; month:01 ; year:2020 ; Free Neuropathology ; 1 (30.01.2020)

Beteiligte, Orts- und Zeitangaben

• Urheber: Planas, Anna Maria

Weitere Informationen

• URN: urn:nbn:de:hbz:6:3-freeneuropathology-2020-25168
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 14.08.2025, 10:49 MESZ